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Nubp2 Gene Detail
Summary
  • Symbol
    Nubp2
  • Name
    nucleotide binding protein 2
  • Synonyms
    D17Wsu11e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347072
    NCBI Gene: 26426
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25101585-25105323 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347072
 protein coding gene Chr17:25101585-25105423 (-)
129S1/SvImJ ENSMUSG00200047829
 protein coding gene Chr17:20546298-20550645 (-)
A/J ENSMUSG00195052714
 protein coding gene Chr17:21565972-21570082 (-)
AKR/J ENSMUSG00220050478
 protein coding gene Chr17:20610762-20617029 (-)
BALB/cJ ENSMUSG00180037008
 protein coding gene Chr17:20844540-20848610 (-)
C3H/HeJ ENSMUSG00175040589
 protein coding gene Chr17:20603194-20607264 (-)
C57BL/6NJ ENSMUSG00215052499
 protein coding gene Chr17:20609322-20614535 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021210
 protein coding gene Chr17:20705116-20708795 (-)
CAST/EiJ ENSTCUG00005041938
 protein coding gene Chr17:21184722-21189121 (-)
CBA/J ENSMUSG00210042081
 protein coding gene Chr17:20442039-20446109 (-)
DBA/2J ENSMUSG00185048639
 protein coding gene Chr17:22654277-22658387 (-)
FVB/NJ ENSMUSG00205044219
 protein coding gene Chr17:20906786-20911133 (-)
JF1/MsJ ENSUMUG00000039418
 protein coding gene Chr17:22100772-22105125 (-)
LP/J ENSMUSG00230054684
 protein coding gene Chr17:24051216-24055286 (-)
NOD/ShiLtJ ENSMUSG00190053881
 protein coding gene Chr17:20543026-20547136 (-)
NZO/HlLtJ ENSMUSG00225051962
 protein coding gene Chr17:25973408-25977518 (-)
PWK/PhJ ENSLUMG00010018312
 protein coding gene Chr17:20014520-20019954 (-)
SPRET/EiJ ENSMSPG00010048592
 protein coding gene Chr17:21351110-21354839 (-)
WSB/EiJ ENSIUOG00005039475
 protein coding gene Chr17:21290628-21295459 (-)



Homology
more
  • Human Ortholog
    NUBP2, NUBP iron-sulfur cluster assembly factor 2, cytosolic
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUBP2, NUBP iron-sulfur cluster assembly factor 2, cytosolic
  • Synonyms
    CFD1, CIAO6, NBP 2
  • Links
    NCBI Gene ID: 10101
    UniProt: Q9Y5Y2

  • Chr Location
    16p13.3; chr16:1782932-1789189 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    620
  • Tissues
    17
  • cDNA Data
    81
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039183 Ensembl Gene Model | MGI Sequence Detail 3739 C57BL/6J ±  kb
    transcript ENSMUST00000044252 Ensembl | MGI Sequence Detail 1427 Not Applicable  
    polypeptide ENSMUSP00000049319 Ensembl | MGI Sequence Detail 275 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000011477 cytosolic Fe-S cluster assembly factor NUBP2
      (term hierarchy)
    • InterPro Domains
      IPR028600 Cytosolic Fe-S cluster assembly factor NUBP2/Cfd1, eukaryotes
      IPR033756 Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35
      IPR000808 Iron-sulfur cluster carrier protein-like, conserved site
      IPR019591 Mrp/NBP35 ATP-binding protein
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q9R061 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 81
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-33980, MGI:106288
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory