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Psmb2 Gene Detail
Summary
  • Symbol
    Psmb2
  • Name
    proteasome (prosome, macropain) subunit, beta type 2
  • Synonyms
    D4Wsu33e, HC7-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347045
    NCBI Gene: 26445
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:126571423-126603507 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 60.90 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347045
 protein coding gene Chr4:126571421-126603508 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028785
 protein coding gene Chr4:128384931-128417813 (+)
A/J MGP_AJ_G0028744
 protein coding gene Chr4:123324504-123357117 (+)
AKR/J MGP_AKRJ_G0028697
 protein coding gene Chr4:126713390-126745451 (+)
BALB/cJ MGP_BALBcJ_G0028767
 protein coding gene Chr4:123897429-123929431 (+)
C3H/HeJ MGP_C3HHeJ_G0028481
 protein coding gene Chr4:126786221-126818765 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029209
 protein coding gene Chr4:133274130-133307574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026482
 protein coding gene Chr4:116454385-116487380 (+)
CAST/EiJ MGP_CASTEiJ_G0027914
 protein coding gene Chr4:124896585-124931220 (+)
CBA/J MGP_CBAJ_G0028447
 protein coding gene Chr4:136495587-136529641 (+)
DBA/2J MGP_DBA2J_G0028596
 protein coding gene Chr4:123770788-123803063 (+)
FVB/NJ MGP_FVBNJ_G0028563
 protein coding gene Chr4:122429284-122461331 (+)
LP/J MGP_LPJ_G0028697
 protein coding gene Chr4:128664889-128699131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028589
 protein coding gene Chr4:141513176-141546094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029247
 protein coding gene Chr4:127073313-127106101 (+)
PWK/PhJ MGP_PWKPhJ_G0027635
 protein coding gene Chr4:120267432-120300184 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027461
 protein coding gene Chr4:122903710-122937677 (+)
WSB/EiJ MGP_WSBEiJ_G0027994
 protein coding gene Chr4:127186765-127221255 (+)



Homology
more
  • Human Ortholog
    PSMB2, proteasome 20S subunit beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMB2, proteasome 20S subunit beta 2
  • Synonyms
    HC7-I
  • Links
    NCBI Gene ID: 5690
    neXtProt AC: NX_P49721
    UniProt: P49721

  • Chr Location
    1p34.3; chr1:35599541-35641526 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    3
  • cDNA Data
    9
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028837 Ensembl Gene Model | MGI Sequence Detail 32085 C57BL/6J ±  kb
transcript ENSMUST00000030642 Ensembl | MGI Sequence Detail 859 Not Applicable  
polypeptide ENSMUSP00000030642 Ensembl | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-34196, MGI:106502, MGI:2140499, MGI:2140555
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:329885 Belanger C, et al., CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms. FASEB J. 2022 Mar;36(3):e22176
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/19/2023
MGI 6.22 		The Jackson Laboratory