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Psma5 Gene Detail
Summary
  • Symbol
    Psma5
  • Name
    proteasome subunit alpha 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347009
    NCBI Gene: 26442
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108164242-108187268 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    609 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347009
 protein coding gene Chr3:108164242-108187290 (+)
129S1/SvImJ ENSMUSG00200035046
 protein coding gene Chr3:104780236-104803284 (+)
A/J ENSMUSG00195025049
 protein coding gene Chr3:105206695-105229745 (+)
AKR/J ENSMUSG00220030310
 protein coding gene Chr3:103570331-103593379 (+)
BALB/cJ ENSMUSG00180015709
 protein coding gene Chr3:105152041-105175095 (+)
C3H/HeJ ENSMUSG00175029056
 protein coding gene Chr3:104686794-104709844 (+)
C57BL/6NJ ENSMUSG00215023664
 protein coding gene Chr3:105414665-105437713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025526
 protein coding gene Chr3:102463482-102485887 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210007423
 protein coding gene Chr3:105308659-105331707 (+)
DBA/2J ENSMUSG00185019780
 protein coding gene Chr3:105777994-105801044 (+)
FVB/NJ ENSMUSG00205022929
 protein coding gene Chr3:104344658-104367701 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230014626
 protein coding gene Chr3:107693224-107716273 (+)
NOD/ShiLtJ ENSMUSG00190026661
 protein coding gene Chr3:106016077-106039126 (+)
NZO/HlLtJ ENSMUSG00225018447
 protein coding gene Chr3:110194228-110217082 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010033250
 protein coding gene Chr3:105114221-105136838 (+)
WSB/EiJ ENSIUOG00005004075
 protein coding gene Chr3:105330527-105353557 (+)



Homology
more
  • Human Ortholog
    PSMA5, proteasome 20S subunit alpha 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMA5, proteasome 20S subunit alpha 5
  • Synonyms
    PSC5, ZETA
  • Links
    NCBI Gene ID: 5686
    UniProt: P28066

  • Chr Location
    1p13.3; chr1:109399042-109426471 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit spine deformities, ataxia, abnormal gait, and reduced body size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    229
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26442 NCBI Gene Model | MGI Sequence Detail 23027 C57BL/6J ±  kb
    transcript NM_011967 RefSeq | MGI Sequence Detail 1217 C57BL/6  
    polypeptide Q9Z2U1 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 229
      cDNA 229

      Microarray probesets 4
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:57232 Elenich LA, et al., The complete primary structure of mouse 20S proteasomes. Immunogenetics. 1999 Sep;49(10):835-42
    • Latest
      J:347599 Raja R, et al., Insertion of a neomycin selection cassette in the Amigo1 locus alters gene expression in the olfactory epithelium leading to region-specific defects in olfactory receptor neuron development. Genesis. 2024 Apr;62(2):e23594
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory