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Lypla2 Gene Detail
Summary
  • Symbol
    Lypla2
  • Name
    lysophospholipase 2
  • Synonyms
    LysoII, lysophospholipase II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347000
    NCBI Gene: 26394
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135695535-135699937 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.33 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347000
 protein coding gene Chr4:135695535-135700954 (-)
129S1/SvImJ ENSMUSG00200019740
 protein coding gene Chr4:129113519-129117923 (-)
A/J ENSMUSG00195036467
 protein coding gene Chr4:130467441-130471843 (-)
AKR/J ENSMUSG00220046719
 protein coding gene Chr4:129461182-129465588 (-)
BALB/cJ ENSMUSG00180045464
 protein coding gene Chr4:128100073-128104479 (-)
C3H/HeJ ENSMUSG00175033774
 protein coding gene Chr4:129120429-129124835 (-)
C57BL/6NJ ENSMUSG00215052060
 protein coding gene Chr4:130635354-130639756 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026651
 protein coding gene Chr4:125638664-125643062 (-)
CAST/EiJ ENSTCUG00005045391
 protein coding gene Chr4:130039867-130044271 (-)
CBA/J ENSMUSG00210053334
 protein coding gene Chr4:128744340-128748746 (-)
DBA/2J ENSMUSG00185052118
 protein coding gene Chr4:130273382-130277788 (-)
FVB/NJ ENSMUSG00205046989
 protein coding gene Chr4:128516811-128521218 (-)
JF1/MsJ ENSUMUG00000041753
 protein coding gene Chr4:130969825-130974229 (-)
LP/J ENSMUSG00230035606
 protein coding gene Chr4:134051796-134056200 (-)
NOD/ShiLtJ ENSMUSG00190035743
 protein coding gene Chr4:128505524-128509930 (-)
NZO/HlLtJ ENSMUSG00225025590
 protein coding gene Chr4:140006638-140011042 (-)
PWK/PhJ ENSLUMG00010038380
 protein coding gene Chr4:127952509-127956911 (-)
SPRET/EiJ ENSMSPG00010033701
 protein coding gene Chr4:130018026-130022450 (-)
WSB/EiJ ENSIUOG00005036627
 protein coding gene Chr4:128408563-128412969 (-)



Homology
more
  • Human Ortholog
    LYPLA2, lysophospholipase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LYPLA2, lysophospholipase 2
  • Synonyms
    APT-2, APT2, DJ886K2.4
  • Links
    NCBI Gene ID: 11313
    UniProt: O95372

  • Chr Location
    1p36.11; chr1:23791110-23795544 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotype references
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    7
  • Gene trapped
    6
  • Targeted
    7
  • Genomic Mutations
    3 involving Lypla2
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    96
  • cDNA Data
    100
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028670 Ensembl Gene Model | MGI Sequence Detail 4403 C57BL/6J ±  kb
transcript ENSMUST00000105852 Ensembl | MGI Sequence Detail 1588 Not Applicable  
polypeptide ENSMUSP00000101478 Ensembl | MGI Sequence Detail 231 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Developmental Gene Expression 3
    Gene Ontology 12
    Phenotypes 19
  • Earliest
    J:55956 Toyoda T, et al., Sequence, expression in Escherichia coli, and characterization of lysophospholipase II. Biochim Biophys Acta. 1999 Feb 25;1437(2):182-93
  • Latest
    J:369888 Zhang M, et al., SMAD2 S-palmitoylation promotes its linker region phosphorylation and T(H)17 cell differentiation in a mouse model of multiple sclerosis. Sci Signal. 2025 May 27;18(888):eadr2008
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory