Map4k2 MGI Mouse Gene Detail - MGI:1346883 - mitogen-activated protein kinase kinase kinase kinase 2

Symbol

Map4k2
Name

mitogen-activated protein kinase kinase kinase kinase 2
Synonyms

BL44, Rab8ip

Feature Type

protein coding gene
IDs

MGI:1346883
NCBI Gene: 26412
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:6391165-6405645 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.46 cM, cytoband A
Mapping Data

3 experiments

SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346883	protein coding gene	Chr19:6391023-6405649 (+)
129S1/SvImJ	ENSMUSG00200046371	protein coding gene	Chr19:3153855-3168793 (+)
A/J	ENSMUSG00195047840	protein coding gene	Chr19:3561648-3576588 (+)
AKR/J	ENSMUSG00220037901	protein coding gene	Chr19:3327654-3342595 (+)
BALB/cJ	ENSMUSG00180042998	protein coding gene	Chr19:3929232-3944171 (+)
C3H/HeJ	ENSMUSG00175011853	protein coding gene	Chr19:3179389-3194328 (+)
C57BL/6NJ	ENSMUSG00215037809	protein coding gene	Chr19:3392207-3407146 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022606	protein coding gene	Chr19:3127972-3143193 (+)
CAST/EiJ	ENSTCUG00005037774	protein coding gene	Chr19:3312103-3327116 (+)
CBA/J	ENSMUSG00210046197	protein coding gene	Chr19:3183264-3198245 (+)
DBA/2J	ENSMUSG00185039633	protein coding gene	Chr19:3559740-3574719 (+)
FVB/NJ	ENSMUSG00205048182	protein coding gene	Chr19:3560614-3575558 (+)
JF1/MsJ	ENSUMUG00000018783	protein coding gene	Chr19:3528542-3543489 (+)
LP/J	ENSMUSG00230053065	protein coding gene	Chr19:4460721-4475658 (+)
NOD/ShiLtJ	ENSMUSG00190038759	protein coding gene	Chr19:3088972-3103910 (+)
NZO/HlLtJ	ENSMUSG00225026408	protein coding gene	Chr19:8169533-8184471 (+)
PWK/PhJ	ENSLUMG00010004622	protein coding gene	Chr19:3294695-3309657 (+)
SPRET/EiJ	ENSMSPG00010049286	protein coding gene	Chr19:3288234-3302649 (+)
WSB/EiJ	ENSIUOG00005036451	protein coding gene	Chr19:3201485-3216441 (+)

Human Ortholog

MAP4K2, mitogen-activated protein kinase kinase kinase kinase 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP4K2, mitogen-activated protein kinase kinase kinase kinase 2
Synonyms

BL44, GCK, RAB8IP
Links

HGNC:6864

NCBI Gene ID: 5871

UniProt: Q12851
Chr Location

11q13.1; chr11:64784918-64803241 (-) GRCh38

MGI Vertebrate Homology

Map4k2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAP4K2
Protein SuperFamily

MAPKKKK
Gene Tree

Map4k2

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available

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All GO Annotations

32
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

667
Tissues

60
cDNA Data

64
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN map4k2

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All Sequences

102
RefSeq

22
UniProt

10
CCDS

CCDS29503.1

Ensembl

ENSMUSG00000024948 (Evidence)
NCBI Gene

26412

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024948	Ensembl Gene Model \| MGI Sequence Detail	14481	C57BL/6J	± kb
transcript	ENSMUST00000025897	Ensembl \| MGI Sequence Detail	4644	Not Applicable
polypeptide	ENSMUSP00000025897	Ensembl \| MGI Sequence Detail	821	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000010144 mitogen-activated protein kinase kinase kinase kinase 2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR001180 Citron homology (CNH) domain

IPR021160 Mitogen-activated protein (MAP) kinase kinase kinase kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050629 STE20/SPS1-related Proline-Alanine-rich Kinase
GlyGen

Q61161 1 site, 1 O-linked glycan (1 site)

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All nucleic 68

cDNA 67

Primer pair 1

Microarray probesets 6

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MGD-MRK-37069, MGI:108033, MGI:2147514

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 6
Earliest

J:36261 Ren M, et al., In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. Proc Natl Acad Sci U S A. 1996 May 14;93(10):5151-5
Latest

J:382684 Chuang HC, et al., MAP4K2 suppresses antitumor immunity in a pancreatic cancer model by promoting Treg differentiation. J Clin Invest. 2026 Mar 16;136(6)

TSS for Map4k2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154622	Chr19:6391151-6391277 (+)	49 bp
Tssr154623	Chr19:6391453-6391516 (+)	320 bp
Tssr154624	Chr19:6391776-6391823 (+)	635 bp
Tssr154625	Chr19:6392564-6392572 (+)	1,403 bp
Tssr154626	Chr19:6392579-6392590 (+)	1,420 bp
Tssr154627	Chr19:6392592-6392603 (+)	1,433 bp
Tssr154628	Chr19:6393812-6393823 (+)	2,653 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24