Map3k5 MGI Mouse Gene Detail - MGI:1346876 - mitogen-activated protein kinase kinase kinase 5

Symbol

Map3k5
Name

mitogen-activated protein kinase kinase kinase 5
Synonyms

7420452D20Rik, ASK, ASK1, Mekk5

Feature Type

protein coding gene
IDs

MGI:1346876
NCBI Gene: 26408
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr10:19810218-20018499 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 9.35 cM
Mapping Data

2 experiments

SNPs within 2kb

1082 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346876	protein coding gene	Chr10:19809847-20018499 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017051	protein coding gene	Chr10:17666233-17877852 (+)
A/J	MGP_AJ_G0017029	protein coding gene	Chr10:16993973-17193706 (+)
AKR/J	MGP_AKRJ_G0016993	protein coding gene	Chr10:17266899-17498789 (+)
BALB/cJ	MGP_BALBcJ_G0016987	protein coding gene	Chr10:17050012-17263516 (+)
C3H/HeJ	MGP_C3HHeJ_G0016812	protein coding gene	Chr10:17602228-17819462 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017449	protein coding gene	Chr10:18097217-18326352 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015154	protein coding gene	Chr10:15996665-16192173 (+)
CAST/EiJ	MGP_CASTEiJ_G0016394	protein coding gene	Chr10:17478514-17685396 (+)
CBA/J	MGP_CBAJ_G0016784	protein coding gene	Chr10:18918727-19152614 (+)
DBA/2J	MGP_DBA2J_G0016892	protein coding gene	Chr10:16872062-17079181 (+)
FVB/NJ	MGP_FVBNJ_G0016887	protein coding gene	Chr10:16633484-16834094 (+)
LP/J	MGP_LPJ_G0016967	protein coding gene	Chr10:17472800-17677459 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016917	protein coding gene	Chr10:19180823-19400956 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017487	protein coding gene	Chr10:17275400-17484270 (+)
PWK/PhJ	MGP_PWKPhJ_G0016179	protein coding gene	Chr10:16744751-16953744 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015962	protein coding gene	Chr10:17431385-17627092 (+)
WSB/EiJ	MGP_WSBEiJ_G0016456	protein coding gene	Chr10:17360919-17571129 (+)

Human Ortholog

MAP3K5, mitogen-activated protein kinase kinase kinase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K5, mitogen-activated protein kinase kinase kinase 5
Synonyms

ASK1, MAPKKK5, MEKK5
Links

HGNC:6857

NCBI Gene ID: 4217

neXtProt AC: NX_Q99683

UniProt: Q99683
Chr Location

6q23.3; chr6:136557046-136793097 (-) GRCh38

MGI Vertebrate Homology

Map3k5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP3K5
Gene Tree

Map3k5

Diseases

1 with human MAP3K5 associations

				Human Disease	Mouse Models
				Huntington's disease IDs Huntington's disease DOID:12858 ICD10CM:G10 ICD9CM_2006:333.4 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 UMLS_CUI:C0020179

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
73 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Spontaneous

1
Targeted

6
Genomic Mutations

2 involving Map3k5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice are overtly normal, however apoptosis abnormalities are evident in cultured cells and after induced heart damage.

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All GO Annotations

80
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1058
Tissues

253
cDNA Data

35
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MAP3K5

Xenbase map3k5

ZFIN map3k5

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All Sequences

49
RefSeq

4
UniProt

7
CCDS

CCDS35857.1

Ensembl

ENSMUSG00000071369 (Evidence)
NCBI Gene

26408

			Length	Strain/Species	Flank
genomic	ENSMUSG00000071369	Ensembl Gene Model \| MGI Sequence Detail	208282	C57BL/6J	± kb
transcript	ENSMUST00000095806	Ensembl \| MGI Sequence Detail	5450	Not Applicable
polypeptide	ENSMUSP00000093485	Ensembl \| MGI Sequence Detail	1380	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010138 mitogen-activated protein kinase kinase kinase 5

(term hierarchy)
EC

2.7.11.25
InterPro Domains

IPR046872 MAP3K, deoxyribohydrolase domain

IPR046873 MAP3K, HisK-N-like globin domain

IPR043969 MAP3K, PH domain

IPR025136 MAP3K, TRAFs-binding domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 38

cDNA 35

Primer pair 3

Microarray probesets 4

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MGI:1101761, MGI:2445207

Summaries

All 154

Developmental Gene Expression 12

Gene Ontology 16

Phenotypes 73
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:339005 Singh V, et al., Phosphoproteomics identifies pathways underlying the role of receptor-interaction protein kinase 3 in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 as a target. Hepatol Commun. 2022 Aug;6(8):2022-2041

TSS for Map3k5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92555	Chr10:19809303-19809312 (+)	-910 bp
Tssr3151	Chr10:19809325-19809337 (+)	-887 bp
Tssr92556	Chr10:19809344-19809359 (+)	-866 bp
Tssr92557	Chr10:19809361-19809371 (+)	-852 bp
Tssr92558	Chr10:19809433-19809444 (+)	-779 bp
Tssr92559	Chr10:19809670-19809699 (+)	-533 bp
Tssr92560	Chr10:19809816-19809851 (+)	-384 bp
Tssr92561	Chr10:19809926-19809944 (+)	-283 bp
Tssr92562	Chr10:19809980-19810032 (+)	-212 bp
Tssr92563	Chr10:19810038-19810063 (+)	-167 bp
Tssr3152	Chr10:19815227-19815238 (+)	5,015 bp
Tssr3153	Chr10:19815267-19815276 (+)	5,054 bp
Tssr92564	Chr10:19832863-19832869 (+)	22,648 bp
Tssr92565	Chr10:19886104-19886107 (+)	75,888 bp
Tssr92566	Chr10:19980610-19980629 (+)	170,402 bp
Tssr92567	Chr10:20017628-20017634 (+)	207,413 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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