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Mta2 Gene Detail
Summary
  • Symbol
    Mta2
  • Name
    metastasis-associated gene family, member 2
  • Synonyms
    mmta2, Mta1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346340
    NCBI Gene: 23942
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8919284-8929664 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.04 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346340
 protein coding gene Chr19:8919239-8929667 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024825
 protein coding gene Chr19:6229459-6241068 (+)
A/J MGP_AJ_G0024793
 protein coding gene Chr19:5894615-5905279 (+)
AKR/J MGP_AKRJ_G0024768
 protein coding gene Chr19:5994153-6004145 (+)
BALB/cJ MGP_BALBcJ_G0024793
 protein coding gene Chr19:6004536-6014576 (+)
C3H/HeJ MGP_C3HHeJ_G0024559
 protein coding gene Chr19:6081035-6092131 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025240
 protein coding gene Chr19:6365451-6375458 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022669
 protein coding gene Chr19:6151868-6161784 (+)
CAST/EiJ MGP_CASTEiJ_G0024032
 protein coding gene Chr19:5731577-5741631 (+)
CBA/J MGP_CBAJ_G0024533
 protein coding gene Chr19:6485953-6496040 (+)
DBA/2J MGP_DBA2J_G0024660
 protein coding gene Chr19:5729740-5740013 (+)
FVB/NJ MGP_FVBNJ_G0024627
 protein coding gene Chr19:5801070-5811315 (+)
LP/J MGP_LPJ_G0024747
 protein coding gene Chr19:6126297-6136304 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024654
 protein coding gene Chr19:6342358-6355597 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025289
 protein coding gene Chr19:6041422-6052857 (+)
PWK/PhJ MGP_PWKPhJ_G0023777
 protein coding gene Chr19:5402795-5413523 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023582
 protein coding gene Chr19:5652465-5662369 (+)
WSB/EiJ MGP_WSBEiJ_G0024094
 protein coding gene Chr19:6010351-6022119 (+)



Homology
more
  • Human Ortholog
    MTA2, metastasis associated 1 family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTA2, metastasis associated 1 family member 2
  • Synonyms
    MTA1L1, PID
  • Links
    NCBI Gene ID: 9219
    neXtProt AC: NX_O94776
    UniProt: O94776

  • Chr Location
    11q12.3; chr11:62593203-62601840 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Mta2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit partial embryonic and perinatal lethality, reduced weight, shortened lifespan, and increased susceptibility to systemic lupus erythematosus with increased T cell proliferation under Th2 conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    91
  • cDNA Data
    208
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23942 NCBI Gene Model | MGI Sequence Detail 10381 C57BL/6J ±  kb
    transcript NM_001412946 RefSeq | MGI Sequence Detail 3262 C57BL/6  
    polypeptide Q9R190 UniProt | EBI | MGI Sequence Detail 668 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 211
      Genomic 1
      cDNA 209
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2147745
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 25
      Phenotypes 12
    • Earliest
      J:56739 Zhang Y, et al., Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 1999 Aug 1;13(15):1924-35
    • Latest
      J:325504 Price JD, et al., DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression. Development. 2022 Jun 1;149(11):dev199508
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/14/2023
    MGI 6.22     		The Jackson Laboratory