Srp54a MGI Mouse Gene Detail - MGI:1346087 - signal recognition particle 54A

Symbol

Srp54a
Name

signal recognition particle 54A
Synonyms

54kDa, 54K subunit of signal recognition particle, Srp54

Feature Type

protein coding gene
IDs

MGI:1346087
NCBI Gene: 24067
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:55127318-55162152 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 23.86 cM
Mapping Data

1 experiment

SNPs within 2kb

250 from dbSNP Build 142
Strain Annotations

12

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346087	protein coding gene	Chr12:55127047-55162152 (+)
129S1/SvImJ	ENSMUSG00200030132	protein coding gene	Chr12:47110658-47145774 (+)
A/J	ENSMUSG00195016737	protein coding gene	Chr12:49676238-49711231 (+)
AKR/J	ENSMUSG00220025657	protein coding gene	Chr12:47694595-47729588 (+)
BALB/cJ	no annotation
C3H/HeJ	ENSMUSG00175016369	protein coding gene	Chr12:51738307-51773299 (+)
C57BL/6NJ	ENSMUSG00215012395	protein coding gene	Chr12:48044918-48080027 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210009478	protein coding gene	Chr12:48212598-48247590 (+)
DBA/2J	ENSMUSG00185000934	protein coding gene	Chr12:50158027-50193019 (+)
FVB/NJ	ENSMUSG00205012095	protein coding gene	Chr12:47999022-48034105 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230014852	protein coding gene	Chr12:57187652-57222766 (+)
NOD/ShiLtJ	ENSMUSG00190015744	protein coding gene	Chr12:47206424-47241415 (+)
NZO/HlLtJ	ENSMUSG00225040529	protein coding gene	Chr12:59331576-59366690 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

SRP54, signal recognition particle 54

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRP54, signal recognition particle 54
Synonyms

SCN8
Links

HGNC:11301

NCBI Gene ID: 6729

UniProt: P61011
Chr Location

14q13.2; chr14:34981957-35029686 (+) GRCh38

MGI Vertebrate Homology

Srp54a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRP54
Gene Tree

Srp54a

Diseases

1 with human SRP54 associations

				Human Disease	Mouse Models
				severe congenital neutropenia 8 IDs severe congenital neutropenia 8 DOID:0112135 OMIM:618752

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotype references

All Mutations and Alleles

1
Chemically induced (other)

1
Genomic Mutations

1 involving Srp54a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

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All GO Annotations

39
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN srp54

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All Sequences

46
RefSeq

14
UniProt

2
CCDS

CCDS36449.1

Ensembl

ENSMUSG00000073079 (Evidence)
NCBI Gene

24067

			Length	Strain/Species	Flank
genomic	24067	NCBI Gene Model \| MGI Sequence Detail	34835	C57BL/6J	± kb
transcript	NM_001413631	RefSeq \| MGI Sequence Detail	4233	C57BL/6
polypeptide	P14576	UniProt \| EBI \| MGI Sequence Detail	504	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015625 signal recognition particle subunit SRP54

(term hierarchy)

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All nucleic 6

cDNA 6

Microarray probesets 2

Summaries

All 28

Gene Ontology 7

Phenotypes 2
Earliest

J:25672 Bernstein HD, et al., Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature. 1989 Aug 10;340(6233):482-6
Latest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573

TSS for Srp54a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113479	Chr12:55126999-55127020 (+)	-308 bp
Tssr113480	Chr12:55127313-55127345 (+)	11 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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