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Tlk2 Gene Detail
Summary
  • Symbol
    Tlk2
  • Name
    tousled-like kinase 2 (Arabidopsis)
  • Synonyms
    4933403M19Rik, PKUalpha, protein kinase U-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346023
    NCBI Gene: 24086
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:105069633-105174785 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 68.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2015 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346023
protein coding gene Chr11:105066869-105174785 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019283
protein coding gene Chr11:108399010-108509935 (+)
A/J MGP_AJ_G0019251
protein coding gene Chr11:103777383-103883043 (+)
AKR/J MGP_AKRJ_G0019220
protein coding gene Chr11:106912937-107020071 (+)
BALB/cJ MGP_BALBcJ_G0019225
protein coding gene Chr11:104198676-104303074 (+)
C3H/HeJ MGP_C3HHeJ_G0019034
protein coding gene Chr11:107196870-107304266 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019675
protein coding gene Chr11:111767365-111878231 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017300
protein coding gene Chr11:101119925-101221035 (+)
CAST/EiJ MGP_CASTEiJ_G0018587
protein coding gene Chr11:108239387-108352923 (+)
CBA/J MGP_CBAJ_G0019003
protein coding gene Chr11:116397166-116515332 (+)
DBA/2J MGP_DBA2J_G0019115
protein coding gene Chr11:103270050-103374767 (+)
FVB/NJ MGP_FVBNJ_G0019106
protein coding gene Chr11:102781494-102887494 (+)
LP/J MGP_LPJ_G0019185
protein coding gene Chr11:108864128-108982164 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019136
protein coding gene Chr11:115666273-115787903 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019712
protein coding gene Chr11:107386673-107497371 (+)
PWK/PhJ MGP_PWKPhJ_G0018352
protein coding gene Chr11:104353048-104462572 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018143
protein coding gene Chr11:107137451-107248177 (+)
WSB/EiJ MGP_WSBEiJ_G0018638
protein coding gene Chr11:107351089-107461487 (+)



Homology
more
  • Human Ortholog
    TLK2, tousled like kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLK2, tousled like kinase 2
  • Synonyms
    HsHPK, MRD57, PKU-ALPHA
  • Links
    NCBI Gene ID: 11011
    neXtProt AC: NX_Q86UE8
    UniProt: Q86UE8

  • Chr Location
    17q23.2; chr17:62458658-62615481 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TLK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of this gene causes late embryonic lethality due to placental failure. Observed phenotypes include a small, hypocellular and poorly vascularized placenta with a disorganized labyrinth, and reduced numbers of syncytiotrophoblast, spongiotrophoblast and trophoblastic giant cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020694 Ensembl Gene Model | MGI Sequence Detail 105153 C57BL/6J ±  kb
    transcript ENSMUST00000106941 Ensembl | MGI Sequence Detail 3699 Not Applicable  
    polypeptide ENSMUSP00000102554 Ensembl | MGI Sequence Detail 750 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      cDNA 136

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1918299
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:53339 Shalom S, et al., Tlk, a novel evolutionarily conserved murine serine threonine kinase, encodes multiple testis transcripts. Mol Reprod Dev. 1999 Apr;52(4):392-405
    • Latest
      J:351320 Lin HY, et al., The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1beta-mediated AML progression. Blood. 2024 Jun 27;143(26):2749-2762

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory