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Clpx Gene Detail
Summary
  • Symbol
    Clpx
  • Name
    caseinolytic mitochondrial matrix peptidase chaperone subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346017
    NCBI Gene: 270166
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:65201542-65237940 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 35.22 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    823 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346017
 protein coding gene Chr9:65201533-65237940 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034953
 protein coding gene Chr9:65016878-65057739 (+)
A/J MGP_AJ_G0034933
 protein coding gene Chr9:62830918-62866835 (+)
AKR/J MGP_AKRJ_G0034863
 protein coding gene Chr9:64306208-64349551 (+)
BALB/cJ MGP_BALBcJ_G0034926
 protein coding gene Chr9:62552338-62588915 (+)
C3H/HeJ MGP_C3HHeJ_G0034636
 protein coding gene Chr9:64838264-64875509 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035445
 protein coding gene Chr9:66789490-66827289 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032356
 protein coding gene Chr9:62479685-62518254 (+)
CAST/EiJ MGP_CASTEiJ_G0033957
 protein coding gene Chr9:65030489-65067827 (+)
CBA/J MGP_CBAJ_G0034607
 protein coding gene Chr9:69116137-69156519 (+)
DBA/2J MGP_DBA2J_G0034766
 protein coding gene Chr9:62602144-62638109 (+)
FVB/NJ MGP_FVBNJ_G0034708
 protein coding gene Chr9:61922876-61960128 (+)
LP/J MGP_LPJ_G0034849
 protein coding gene Chr9:65296681-65332101 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034750
 protein coding gene Chr9:70356746-70395319 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035467
 protein coding gene Chr9:64411992-64448678 (+)
PWK/PhJ MGP_PWKPhJ_G0033661
 protein coding gene Chr9:62802054-62840356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033495
 protein coding gene Chr9:64700627-64738714 (+)
WSB/EiJ MGP_WSBEiJ_G0034070
 protein coding gene Chr9:64312155-64348868 (+)



Homology
more
  • Human Ortholog
    CLPX, caseinolytic mitochondrial matrix peptidase chaperone subunit X
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLPX, caseinolytic mitochondrial matrix peptidase chaperone subunit X
  • Synonyms
    EPP2
  • Links
    NCBI Gene ID: 10845
    neXtProt AC: NX_O76031
    UniProt: O76031

  • Chr Location
    15q22.31; chr15:65148219-65185342 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CLPX associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    60
  • cDNA Data
    73
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015357 Ensembl Gene Model | MGI Sequence Detail 36399 C57BL/6J ±  kb
    transcript ENSMUST00000015501 Ensembl | MGI Sequence Detail 2885 Not Applicable  
    polypeptide ENSMUSP00000015501 Ensembl | MGI Sequence Detail 634 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005604 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR003959 ATPase, AAA-type, core
      IPR050052 ATP-dependent Clp protease ATP-binding subunit ClpX
      IPR019489 Clp ATPase, C-terminal
      IPR004487 Clp protease, ATP-binding subunit ClpX
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR010603 Zinc finger, ClpX C4-type
    • GlyGen
      Q9JHS4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 73
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143186
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:55436 Santagata S, et al., Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family. J Biol Chem. 1999 Jun 4;274(23):16311-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory