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Ptpa Gene Detail
Summary
  • Symbol
    Ptpa
  • Name
    protein phosphatase 2 protein activator
  • Synonyms
    2610042B21Rik, MGC:60706, MGC:7129, Ppp2r4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346006
    NCBI Gene: 110854
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30306062-30337819 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    809 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346006
 protein coding gene Chr2:30306051-30337819 (+)
129S1/SvImJ ENSMUSG00200049083
 protein coding gene Chr2:27303951-27307792 (+)
129S1/SvImJ ENSMUSGG00200054399
 protein coding gene Chr2:27276794-27287176 (+)
A/J ENSMUSGG00195054906
 protein coding gene Chr2:27370393-27380786 (+)
A/J ENSMUSG00195040654
 protein coding gene Chr2:27397409-27401253 (+)
AKR/J ENSMUSGG00220054314
 protein coding gene Chr2:27488953-27499345 (+)
AKR/J ENSMUSG00220050368
 protein coding gene Chr2:27515969-27519813 (+)
BALB/cJ ENSMUSGG00180054986
 protein coding gene Chr2:27389727-27400110 (+)
BALB/cJ ENSMUSG00180053694
 protein coding gene Chr2:27416892-27420733 (+)
C3H/HeJ ENSMUSGG00175055170
 protein coding gene Chr2:27359023-27369409 (+)
C3H/HeJ ENSMUSG00175053461
 protein coding gene Chr2:27386183-27390024 (+)
C57BL/6NJ ENSMUSGG00215055702
 protein coding gene Chr2:27424674-27435057 (+)
C57BL/6NJ ENSMUSG00215042715
 protein coding gene Chr2:27451834-27455675 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023396
 protein coding gene Chr2:26278301-26310566 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210017171
 protein coding gene Chr2:27459114-27462955 (+)
CBA/J ENSMUSGG00210055116
 protein coding gene Chr2:27431961-27442341 (+)
DBA/2J ENSMUSGG00185057337
 protein coding gene Chr2:27284447-27294836 (+)
DBA/2J ENSMUSG00185047750
 protein coding gene Chr2:27311459-27315303 (+)
FVB/NJ ENSMUSG00205049357
 protein coding gene Chr2:27163547-27167391 (+)
FVB/NJ ENSMUSGG00205054637
 protein coding gene Chr2:27136529-27146923 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230044255
 protein coding gene Chr2:29239634-29243475 (+)
LP/J ENSMUSGG00230055297
 protein coding gene Chr2:29212479-29222861 (+)
NOD/ShiLtJ ENSMUSG00190035414
 protein coding gene Chr2:27418195-27422039 (+)
NOD/ShiLtJ ENSMUSGG00190055096
 protein coding gene Chr2:27391183-27401572 (+)
NZO/HlLtJ ENSMUSG00225008055
 protein coding gene Chr2:36989155-36992996 (+)
NZO/HlLtJ ENSMUSGG00225055725
 protein coding gene Chr2:36962006-36972385 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010041085
 protein coding gene Chr2:28000337-28019600 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PTPA, protein phosphatase 2 phosphatase activator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPA, protein phosphatase 2 phosphatase activator
  • Synonyms
    PARK25, PP2A, PPP2R4, PR53
  • Links
    NCBI Gene ID: 5524
    UniProt: Q15257

  • Chr Location
    9q34.11; chr9:129110550-129148946 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTPA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    4
  • cDNA Data
    245
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 110854 NCBI Gene Model | MGI Sequence Detail 31758 C57BL/6J ±  kb
transcript NM_001362733 RefSeq | MGI Sequence Detail 2583 ZRU/MplStud  
polypeptide P58389 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000013142 serine/threonine-protein phosphatase 2A regulatory subunit B'
    (term hierarchy)
  • EC
    5.2.1.8
  • InterPro Domains
    IPR043170 Phosphotyrosyl phosphatase activator, C-terminal lid domain
    IPR004327 Phosphotyrosyl phosphatase activator, PTPA
    IPR037218 PTPA superfamily
  • GlyGen
    P58389 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 245
    cDNA 245

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923815, MGI:2139462, MGI:2139539
References
more
  • Summaries
    All 56
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory