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Gtf2h2 Gene Detail
Summary
  • Symbol
    Gtf2h2
  • Name
    general transcription factor II H, polypeptide 2
  • Synonyms
    44kDa, basal transcription factor 2, p44 subunit, Btf2p44, p44
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345669
    NCBI Gene: 23894
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100596726-100629087 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 53.21 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    998 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345669
 protein coding gene Chr13:100596726-100629123 (-)
129S1/SvImJ ENSMUSG00200008428
 protein coding gene Chr13:95094144-95122450 (-)
A/J ENSMUSG00195028180
 protein coding gene Chr13:95641614-95669940 (-)
AKR/J ENSMUSG00220024802
 protein coding gene Chr13:94063665-94091987 (-)
BALB/cJ ENSMUSG00180032485
 protein coding gene Chr13:96180765-96209081 (-)
C3H/HeJ ENSMUSG00175015257
 protein coding gene Chr13:96279294-96307612 (-)
C57BL/6NJ ENSMUSG00215020311
 protein coding gene Chr13:96250676-96278993 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018841
 protein coding gene Chr13:94230593-94265882 (-)
CAST/EiJ ENSTCUG00005011530
 protein coding gene Chr13:95416439-95444853 (-)
CBA/J ENSMUSG00210011533
 protein coding gene Chr13:95602416-95630720 (-)
DBA/2J ENSMUSG00185018290
 protein coding gene Chr13:99346415-99374725 (-)
FVB/NJ ENSMUSG00205027320
 protein coding gene Chr13:94974574-95002893 (-)
JF1/MsJ ENSUMUG00000017480
 protein coding gene Chr13:98977367-99005675 (-)
LP/J ENSMUSG00230032189
 protein coding gene Chr13:109507394-109535700 (-)
NOD/ShiLtJ ENSMUSG00190034659
 protein coding gene Chr13:95934606-95962923 (-)
NZO/HlLtJ ENSMUSG00225036681
 protein coding gene Chr13:101860999-101889305 (-)
PWK/PhJ ENSLUMG00010024033
 protein coding gene Chr13:95005506-95034072 (-)
SPRET/EiJ ENSMSPG00010007856
 protein coding gene Chr13:96356412-96387854 (-)
WSB/EiJ ENSIUOG00005031965
 protein coding gene Chr13:95016612-95044900 (-)



Homology
more
  • Human Ortholog
    GTF2H2, general transcription factor IIH subunit 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2H2, general transcription factor IIH subunit 2
  • Synonyms
    BTF2, BTF2 p44, BTF2P44, p44, T-BTF2P44, TFIIH
  • Links
    NCBI Gene ID: 2966
    UniProt: Q13888

  • Chr Location
    5q13.2; chr5:71034962-71067723 (-)  GRCh38
  • Human Ortholog
    GTF2H2C, GTF2H2 family member C
  • Links
    NCBI Gene ID: 728340
    UniProt: Q6P1K8

  • Chr Location
    5q13.2
  • Human Ortholog
    GTF2H2C_2, GTF2H2 family member C, copy 2
  • Synonyms
    GTF2H2D
  • Links
    NCBI Gene ID: 730394
    UniProt: Q6P1K8

  • Chr Location
    5
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    156
  • cDNA Data
    14
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021639 Ensembl Gene Model | MGI Sequence Detail 32362 C57BL/6J ±  kb
transcript ENSMUST00000145266 Ensembl | MGI Sequence Detail 1630 Not Applicable  
polypeptide ENSMUSP00000138108 Ensembl | MGI Sequence Detail 398 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    Genomic 11
    cDNA 14
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 54
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:57491 von Deimling F, et al., Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. Hum Genet. 1999 Jul-Aug;105(1-2):17-27
  • Latest
    J:358278 Yang Y, et al., Erythrocytic alpha-Synuclein and the Gut Microbiome: Kindling of the Gut-Brain Axis in Parkinson's Disease. Mov Disord. 2024 Jan;39(1):40-52
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory