Rhof MGI Mouse Gene Detail - MGI:1345629 - ras homolog family member F (in filopodia)

Symbol

Rhof
Name

ras homolog family member F (in filopodia)
Synonyms

Arhf, Ifld1

Feature Type

protein coding gene
IDs

MGI:1345629
NCBI Gene: 23912
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:123256243-123279871 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.77 cM
Mapping Data

4 experiments

SNPs within 2kb

48 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1345629	protein coding gene	Chr5:123241107-123279871 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030064	protein coding gene	Chr5:126786730-126819286 (-)
A/J	MGP_AJ_G0030029	protein coding gene	Chr5:121536874-121566149 (-)
AKR/J	MGP_AKRJ_G0029965	protein coding gene	Chr5:125443968-125481762 (-)
BALB/cJ	MGP_BALBcJ_G0030040	protein coding gene	Chr5:122870290-122900525 (-)
C3H/HeJ	MGP_C3HHeJ_G0029757	protein coding gene	Chr5:126070540-126099637 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030493	protein coding gene	Chr5:131678573-131712736 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027719	protein coding gene	Chr5:116119825-116149449 (-)
CAST/EiJ	MGP_CASTEiJ_G0029166	protein coding gene	Chr5:125177542-125210048 (-)
CBA/J	MGP_CBAJ_G0029727	protein coding gene	Chr5:136842454-136873529 (-)
DBA/2J	MGP_DBA2J_G0029877	protein coding gene	Chr5:121582967-121612163 (-)
FVB/NJ	MGP_FVBNJ_G0029833	protein coding gene	Chr5:120584040-120613510 (-)
LP/J	MGP_LPJ_G0029966	protein coding gene	Chr5:127321060-127354678 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029864	protein coding gene	Chr5:140526378-140558204 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030534	protein coding gene	Chr5:125046497-125077025 (-)
PWK/PhJ	MGP_PWKPhJ_G0028880	protein coding gene	Chr5:120369204-120399848 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028717	protein coding gene	Chr5:122745335-122774372 (-)
WSB/EiJ	MGP_WSBEiJ_G0029241	protein coding gene	Chr5:125715074-125745641 (-)

Human Ortholog

RHOF, ras homolog family member F, filopodia associated

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RHOF, ras homolog family member F, filopodia associated
Synonyms

ARHF, RIF
Links

HGNC:15703

NCBI Gene ID: 54509

neXtProt AC: NX_Q9HBH0

UniProt: Q9HBH0
Chr Location

12q24.31; chr12:121777754-121793688 (-) GRCh38.p7

Alliance of Genome Resources

Rhof stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RHOF
Gene Tree

Rhof

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Rhof
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit macrothrombocytopenia without an effect on filopodia generation. Homozygous knockout also leads to the reduction of the number of B cells in the spleen marginal zone.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RHOF

Xenbase rhof

ZFIN rhof

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Rhof interacts with 294 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

108
RefSeq

68
UniProt

2
CCDS

CCDS39263.1

Ensembl

ENSMUSG00000029449 (Evidence)
NCBI Gene

23912

			Length	Strain/Species	Flank
genomic	23912	NCBI Gene Model \| MGI Sequence Detail	23629	C57BL/6J	± kb
transcript	NM_175092	RefSeq \| MGI Sequence Detail	2143	C57BL/6
polypeptide	Q8BYP3	UniProt \| EBI \| MGI Sequence Detail	211	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013980 Rho-related GTP-binding protein RhoF

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR003578 Small GTPase Rho

IPR005225 Small GTP-binding protein domain

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All nucleic 23

Genomic 1

cDNA 22

Microarray probesets 2

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MGI:2140981, MGI:2141105

Summaries

All 34

Gene Ontology 4

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:274905 Shaverdashvili K, et al., KLF4 activates NFkappaB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. PLoS One. 2019;14(4):e0215746

TSS for Rhof:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr53203	Chr5:123270714-123270741 (-)	9,143 bp
Tssr53202	Chr5:123270640-123270669 (-)	9,216 bp
Tssr53201	Chr5:123270467-123270497 (-)	9,389 bp
Tssr53200	Chr5:123270446-123270466 (-)	9,415 bp
Tssr53199	Chr5:123270365-123270380 (-)	9,498 bp
Tssr53198	Chr5:123270335-123270346 (-)	9,530 bp
Tssr53197	Chr5:123268918-123268931 (-)	10,946 bp
Tssr53196	Chr5:123268908-123268915 (-)	10,959 bp
Tssr53195	Chr5:123268887-123268897 (-)	10,979 bp
Tssr53194	Chr5:123266575-123266586 (-)	13,290 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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