Lypla1 MGI Mouse Gene Detail - MGI:1344588

Symbol

Lypla1
Name

lysophospholipase 1
Synonyms

Gm39587, Pla1a

Feature Type

protein coding gene
IDs

MGI:1344588
NCBI Gene: 18777
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:4878046-4916958 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 1.79 cM, cytoband A1
Mapping Data

3 experiments

SNPs within 2kb

265 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344588	protein coding gene	Chr1:4878011-4918633 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015811	protein coding gene	Chr1:1844953-1888864 (+)
A/J	MGP_AJ_G0015793	protein coding gene	Chr1:1921697-1965294 (+)
AKR/J	MGP_AKRJ_G0015752	protein coding gene	Chr1:1904246-1947541 (+)
BALB/cJ	MGP_BALBcJ_G0015749	protein coding gene	Chr1:1850320-1891994 (+)
C3H/HeJ	MGP_C3HHeJ_G0015583	protein coding gene	Chr1:1881327-1923572 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016201	protein coding gene	Chr1:1944939-1989568 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013923	protein coding gene	Chr1:1603753-1638592 (+)
CAST/EiJ	MGP_CASTEiJ_G0015163	protein coding gene	Chr1:2058638-2102988 (+)
CBA/J	MGP_CBAJ_G0015557	protein coding gene	Chr1:2065477-2112501 (+)
DBA/2J	MGP_DBA2J_G0015655	protein coding gene	Chr1:1833750-1874042 (+)
FVB/NJ	MGP_FVBNJ_G0015660	protein coding gene	Chr1:1801960-1842524 (+)
LP/J	MGP_LPJ_G0015728	protein coding gene	Chr1:2023047-2068365 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015679	protein coding gene	Chr1:2223449-2274940 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016248	protein coding gene	Chr1:1858918-1905278 (+)
PWK/PhJ	MGP_PWKPhJ_G0014947	protein coding gene	Chr1:1762891-1809195 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014727	protein coding gene	Chr1:2035013-2083852 (+)
WSB/EiJ	MGP_WSBEiJ_G0015227	protein coding gene	Chr1:1863074-1906056 (+)

Human Ortholog

LYPLA1, lysophospholipase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LYPLA1, lysophospholipase 1
Synonyms

APT1, APT-1, hAPT1, LPL1, LPL-I
Links

HGNC:6737

NCBI Gene ID: 10434

neXtProt AC: NX_O75608

UniProt: O75608
Chr Location

8q11.23; chr8:54046367-54102017 (-) GRCh38

MGI Vertebrate Homology

Lypla1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: LYPLA1
Gene Tree

Lypla1

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

134 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

37
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

851
Tissues

129
cDNA Data

112
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lypla1

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All Sequences

61
RefSeq

4
UniProt

7
CCDS

CCDS14806.1, CCDS87810.1

Ensembl

ENSMUSG00000025903 (Evidence)
NCBI Gene

18777

			Length	Strain/Species	Flank
genomic	18777	NCBI Gene Model \| MGI Sequence Detail	38913	C57BL/6J	± kb
transcript	NM_008866	RefSeq \| MGI Sequence Detail	2520	C57BL/6
polypeptide	P97823	UniProt \| EBI \| MGI Sequence Detail	230	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010005 acyl-protein thioesterase 1

(term hierarchy)
EC

3.1.2.-, 3.1.2.22
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR003140 Phospholipase/carboxylesterase/thioesterase

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All nucleic 114

cDNA 114

Microarray probesets 9

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MGI:1096318, MGI:5622472

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 10
Earliest

J:40317 Wang A, et al., Cloning, expression, and catalytic mechanism of murine lysophospholipase I. J Biol Chem. 1997 May 9;272(19):12723-9
Latest

J:343156 Speck SL, et al., Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria. Cell Rep. 2023 Nov 4;42(11):113389

TSS for Lypla1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5801	Chr1:4877865-4877895 (+)	-166 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23