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Cib1 Gene Detail
Summary
  • Symbol
    Cib1
  • Name
    calcium and integrin binding 1
  • Synonyms
    Kip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1344418
    NCBI Gene: 23991
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79876904-79882367 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.55 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1344418
 protein coding gene Chr7:79876895-79882561 (-)
129S1/SvImJ ENSMUSGG00200054918
 protein coding gene Chr7:66694582-66695745 (-)
129S1/SvImJ ENSMUSG00200031302
 protein coding gene Chr7:66698108-66699993 (-)
A/J ENSMUSGG00195055295
 protein coding gene Chr7:71108221-71109387 (-)
A/J ENSMUSG00195013664
 protein coding gene Chr7:71111764-71113644 (-)
AKR/J ENSMUSGG00220054866
 protein coding gene Chr7:64650240-64651406 (-)
AKR/J ENSMUSG00220033463
 protein coding gene Chr7:64653783-64655663 (-)
BALB/cJ ENSMUSG00180012464
 protein coding gene Chr7:67836859-67838739 (-)
BALB/cJ ENSMUSGG00180055470
 protein coding gene Chr7:67833316-67834482 (-)
C3H/HeJ ENSMUSGG00175054967
 protein coding gene Chr7:68606669-68607832 (-)
C3H/HeJ ENSMUSG00175019426
 protein coding gene Chr7:68610195-68612080 (-)
C57BL/6NJ ENSMUSGG00215055481
 protein coding gene Chr7:67703279-67704447 (-)
C57BL/6NJ ENSMUSG00215013137
 protein coding gene Chr7:67706824-67708704 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029895
 protein coding gene Chr7:82786498-82792079 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210023324
 protein coding gene Chr7:68461447-68463332 (-)
CBA/J ENSMUSGG00210054825
 protein coding gene Chr7:68457921-68459084 (-)
DBA/2J ENSMUSG00185041683
 protein coding gene Chr7:72784223-72786108 (-)
DBA/2J ENSMUSGG00185057576
 protein coding gene Chr7:72780697-72781860 (-)
FVB/NJ ENSMUSGG00205054332
 protein coding gene Chr7:68341407-68342573 (-)
FVB/NJ ENSMUSG00205022179
 protein coding gene Chr7:68344950-68346830 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055306
 protein coding gene Chr7:78870183-78871346 (-)
LP/J ENSMUSG00230010861
 protein coding gene Chr7:78873709-78875594 (-)
NOD/ShiLtJ ENSMUSGG00190054941
 protein coding gene Chr7:68597897-68599060 (-)
NOD/ShiLtJ ENSMUSG00190016884
 protein coding gene Chr7:68601423-68603308 (-)
NZO/HlLtJ ENSMUSGG00225055427
 protein coding gene Chr7:77110303-77111469 (-)
NZO/HlLtJ ENSMUSG00225041427
 protein coding gene Chr7:77113846-77115726 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010022478
 protein coding gene Chr7:67438602-67444261 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CIB1, calcium and integrin binding 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIB1, calcium and integrin binding 1
  • Synonyms
    CIB, CIBP, EV3, KIP1, PRKDCIP, SIP2-28
  • Links
    NCBI Gene ID: 10519
    UniProt: Q99828

  • Chr Location
    15q26.1; chr15:90229975-90265759 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CIB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in male infertility due to disruption of the haploid phase of spermatogenesis and is associated with small testis size and loss of elongated spermatids and sperm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    133
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    673
  • Tissues
    50
  • cDNA Data
    137
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23991 NCBI Gene Model | MGI Sequence Detail 5464 C57BL/6J ±  kb
    transcript NM_001421986 RefSeq | MGI Sequence Detail 1462 C57BL/6  
    polypeptide Q9Z0F4 UniProt | EBI | MGI Sequence Detail 191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 1
      cDNA 137
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 5
      Gene Ontology 14
      Phenotypes 32
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory