Cdh18 MGI Mouse Gene Detail - MGI:1344366

Symbol

Cdh18
Name

cadherin 18
Synonyms

B230220E17Rik

Feature Type

protein coding gene
IDs

MGI:1344366
NCBI Gene: 320865
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr15:22549108-23474504 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 8.54 cM
Mapping Data

4 experiments

SNPs within 2kb

6198 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344366	protein coding gene	Chr15:22548984-23477577 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021746	protein coding gene	Chr15:20406401-21369301 (+)
A/J	MGP_AJ_G0021706	protein coding gene	Chr15:19593573-20515246 (+)
AKR/J	MGP_AKRJ_G0021684	protein coding gene	Chr15:20062965-21004754 (+)
BALB/cJ	MGP_BALBcJ_G0021713	protein coding gene	Chr15:19627822-20547490 (+)
C3H/HeJ	MGP_C3HHeJ_G0021489	protein coding gene	Chr15:20081027-21018432 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022152	protein coding gene	Chr15:21230795-22283830 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019692	protein coding gene	Chr15:18211869-19079178 (+)
CAST/EiJ	MGP_CASTEiJ_G0021005	protein coding gene	Chr15:20402704-21376446 (+)
CBA/J	MGP_CBAJ_G0021458	protein coding gene	Chr15:21932570-22983625 (+)
DBA/2J	MGP_DBA2J_G0021582	protein coding gene	Chr15:19421776-20330395 (+)
FVB/NJ	MGP_FVBNJ_G0021560	protein coding gene	Chr15:19026989-19939813 (+)
LP/J	MGP_LPJ_G0021650	protein coding gene	Chr15:20255498-21207651 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021585	protein coding gene	Chr15:24172088-25513385 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022175	protein coding gene	Chr15:20256213-21204908 (+)
PWK/PhJ	MGP_PWKPhJ_G0020748	protein coding gene	Chr15:19579708-20499635 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020586	protein coding gene	Chr15:20025729-20978378 (+)
WSB/EiJ	MGP_WSBEiJ_G0021061	protein coding gene	Chr15:20267052-21218076 (+)

Human Ortholog

CDH18, cadherin 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDH18, cadherin 18
Synonyms

CDH14, CDH14L, CDH24
Links

HGNC:1757

NCBI Gene ID: 1016

neXtProt AC: NX_Q13634

UniProt: Q13634
Chr Location

5p14.3; chr5:19471296-20575873 (-) GRCh38

MGI Vertebrate Homology

Cdh18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDH18
Gene Tree

Cdh18

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Cdh18
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

11
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

881
Tissues

116
cDNA Data

13
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cdh18

less

All Sequences

61
RefSeq

19
UniProt

6
CCDS

CCDS49585.1

Ensembl

ENSMUSG00000040420 (Evidence)
NCBI Gene

320865

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040420	Ensembl Gene Model \| MGI Sequence Detail	925397	C57BL/6J	± kb
transcript	ENSMUST00000164787	Ensembl \| MGI Sequence Detail	2744	Not Applicable
polypeptide	ENSMUSP00000130851	Ensembl \| MGI Sequence Detail	790	Not Applicable

less

UniProt

6 Sequences
InterPro Domains

IPR039808 Cadherin

IPR020894 Cadherin conserved site

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR000233 Cadherin, Y-type LIR-motif

IPR027397 Catenin binding domain superfamily

less

All nucleic 18

cDNA 14

Primer pair 4

Microarray probesets 2

less

MGI:2444914, MGI:3057183

Summaries

All 44

Developmental Gene Expression 6

Gene Ontology 1

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:319470 Polanco J, et al., Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse. Front Mol Neurosci. 2021;14:633719

TSS for Cdh18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130786	Chr15:22548992-22549013 (+)	-105 bp
Tssr4560	Chr15:22549025-22549036 (+)	-77 bp
Tssr130787	Chr15:22549150-22549168 (+)	51 bp
Tssr130788	Chr15:22789742-22789767 (+)	240,647 bp
Tssr130789	Chr15:23036483-23036494 (+)	487,381 bp
Tssr130790	Chr15:23036506-23036527 (+)	487,409 bp
Tssr130791	Chr15:23036535-23036578 (+)	487,449 bp
Tssr130792	Chr15:23038464-23038472 (+)	489,360 bp
Tssr130793	Chr15:23038934-23038938 (+)	489,828 bp
Tssr4561	Chr15:23196721-23196727 (+)	647,616 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23