Zeb1 MGI Mouse Gene Detail - MGI:1344313 - zinc finger E-box binding homeobox 1

Symbol

Zeb1
Name

zinc finger E-box binding homeobox 1
Synonyms

3110032K11Rik, AREB6, [delta]EF1, MEB1, Nil2, Tcf18, Tcf8, Tw, ZEB, Zfhep, Zfhx1a, Zfx1a

Feature Type

protein coding gene
IDs

MGI:1344313
NCBI Gene: 21417
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr18:5591860-5775467 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 4.42 cM
Mapping Data

22 experiments

SNPs within 2kb

3961 from dbSNP Build 142
Strain Annotations

22

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344313	protein coding gene	Chr18:5591330-5775468 (+)
129S1/SvImJ	ENSMUSG00200024041	protein coding gene	Chr18:2518017-2559562 (+)
129S1/SvImJ	ENSMUSGG00200054646	protein coding gene	Chr18:2559409-2697129 (+)
A/J	ENSMUSG00195008357	protein coding gene	Chr18:2703832-2891430 (+)
AKR/J	ENSMUSGG00220054857	protein coding gene	Chr18:2748095-2885827 (+)
AKR/J	ENSMUSG00220018706	protein coding gene	Chr18:2706705-2748248 (+)
BALB/cJ	ENSMUSG00180005221	protein coding gene	Chr18:3172230-3349345 (+)
C3H/HeJ	ENSMUSG00175007102	protein coding gene	Chr18:2707703-2884824 (+)
C57BL/6NJ	ENSMUSG00215013057	protein coding gene	Chr18:2424644-2612239 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021973	protein coding gene	Chr18:2242748-2419338 (+)
CAST/EiJ	ENSTCUG00005016161	protein coding gene	Chr18:2673258-2863064 (+)
CBA/J	ENSMUSG00210021739	protein coding gene	Chr18:2714545-2891663 (+)
DBA/2J	ENSMUSG00185029815	protein coding gene	Chr18:2703597-2891194 (+)
FVB/NJ	ENSMUSG00205029220	protein coding gene	Chr18:2459139-2646736 (+)
JF1/MsJ	ENSUMUG00000030013	protein coding gene	Chr18:2717294-2907848 (+)
LP/J	ENSMUSGG00230055696	protein coding gene	Chr18:4808726-4946453 (+)
LP/J	ENSMUSG00230026057	protein coding gene	Chr18:4767340-4808879 (+)
NOD/ShiLtJ	ENSMUSG00190009862	protein coding gene	Chr18:2466192-2653770 (+)
NZO/HlLtJ	ENSMUSG00225033944	protein coding gene	Chr18:4686774-4874348 (+)
PWK/PhJ	ENSLUMG00010008736	protein coding gene	Chr18:2892010-3089038 (+)
SPRET/EiJ	ENSMSPG00010011270	protein coding gene	Chr18:2430955-2622273 (+)
WSB/EiJ	ENSIUOG00005026215	protein coding gene	Chr18:2620870-2808425 (+)

Human Ortholog

ZEB1, zinc finger E-box binding homeobox 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZEB1, zinc finger E-box binding homeobox 1
Synonyms

AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Links

HGNC:11642

NCBI Gene ID: 6935

UniProt: P37275
Chr Location

10p11.22; chr10:31318417-31529814 (+) GRCh38

MGI Vertebrate Homology

Zeb1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZEB1
Gene Tree

Zeb1

Diseases

1 with Zeb1 mouse models; 2 with human ZEB1 associations

Human Disease

Mouse Models

HTLV-1-associated myelopathy/tropical spastic paraparesis

IDs

View 1 model

Fuchs' endothelial dystrophy

IDs

posterior polymorphous corneal dystrophy 3

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

191 phenotypes from 9 alleles in 16 genetic backgrounds
14 phenotypes from multigenic genotypes
5 images
81 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (ENU)

2
Endonuclease-mediated

9
Gene trapped

3
Spontaneous

1
Targeted

15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

67 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations at this locus affect thymus organization and homozygotes exhibit severe thymic T cell deficiency. Some mutations result in eye anomalies and extensive skeletal abnormalities. Homozygotes generally die at birth due to respiratory failure.

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All GO Annotations

63
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1289
Tissues

368
cDNA Data

31
Literature Summary

63

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ZEB1

Xenbase zeb1

ZFIN zeb1a, zeb1b

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All Sequences

123
RefSeq

52
UniProt

10
CCDS

CCDS29039.1

Ensembl

ENSMUSG00000024238 (Evidence)
NCBI Gene

21417

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024238	Ensembl Gene Model \| MGI Sequence Detail	183608	C57BL/6J	± kb
transcript	ENSMUST00000025081	Ensembl \| MGI Sequence Detail	5801	Not Applicable
polypeptide	ENSMUSP00000025081	Ensembl \| MGI Sequence Detail	1117	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000017617 zinc finger E-box-binding homeobox 1

(term hierarchy)
InterPro Domains

IPR008598 Di19, zinc-binding domain

IPR009057 Homeodomain-like superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

IPR051574 Zinc finger E-box-binding homeobox
GlyGen

Q64318 2 sites, 1 N-linked glycan (1 site)

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All nucleic 49

Genomic 2

cDNA 37

Primer pair 5

Other 5

Antibodies 13

Microarray probesets 5

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MGD-MRK-14760, MGD-MRK-15303, MGD-MRK-19431, MGD-MRK-24149, MGI:1920415, MGI:98508, MGI:98871

Summaries

All 230

Developmental Gene Expression 63

Diseases 1

Gene Ontology 22

Phenotypes 81
Earliest

J:274 LYON MF, Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958 Mar;6(1):105-16
Latest

J:385968 D'Avanzo E, et al., A ZEB1-Neon knock-in uncovers traceable dynamics of epithelial-mesenchymal transition in tumors in vivo. BMC Biol. 2026 May 12;24(1)

TSS for Zeb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149946	Chr18:5591868-5591902 (+)	25 bp
Tssr149947	Chr18:5591910-5591919 (+)	55 bp
Tssr149948	Chr18:5593347-5593351 (+)	1,489 bp
Tssr149949	Chr18:5593566-5593586 (+)	1,716 bp
Tssr149950	Chr18:5593882-5593900 (+)	2,031 bp
Tssr149951	Chr18:5594199-5594230 (+)	2,355 bp
Tssr149952	Chr18:5603739-5603761 (+)	11,890 bp
Tssr149953	Chr18:5603762-5603776 (+)	11,909 bp
Tssr149954	Chr18:5625968-5625972 (+)	34,110 bp
Tssr149955	Chr18:5669262-5669269 (+)	77,406 bp
Tssr5239	Chr18:5671156-5671159 (+)	79,298 bp
Tssr149956	Chr18:5688820-5688823 (+)	96,962 bp
Tssr5240	Chr18:5721377-5721384 (+)	129,521 bp
Tssr149957	Chr18:5772694-5772707 (+)	180,841 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24