Lrrfip1 MGI Mouse Gene Detail - MGI:1342770 - leucine rich repeat (in FLII) interacting protein 1

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Lrrfip1 Gene Detail

Symbol

Lrrfip1
Name

leucine rich repeat (in FLII) interacting protein 1
Synonyms

FLAP (FLI LRR associated protein), Fliiap1

Feature Type

protein coding gene
IDs

MGI:1342770
NCBI Gene: 16978
Alliance

genome feature page
Transcription Start Sites

31 TSS

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Sequence Map

Chr1:90926459-91056666 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 46.03 cM
Mapping Data

2 experiments

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SNPs within 2kb

3900 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1342770	protein coding gene	Chr1:90924652-91056666 (+)
129S1/SvImJ	ENSMUSGG00200054452	protein coding gene	Chr1:88153866-88276099 (+)
A/J	ENSMUSGG00195055106	protein coding gene	Chr1:87707967-87828518 (+)
AKR/J	ENSMUSGG00220054545	protein coding gene	Chr1:87863212-87985442 (+)
BALB/cJ	ENSMUSGG00180055212	protein coding gene	Chr1:88023855-88142466 (+)
C3H/HeJ	ENSMUSGG00175054596	protein coding gene	Chr1:87893824-88014358 (+)
C57BL/6NJ	ENSMUSGG00215055295	protein coding gene	Chr1:87826869-87945458 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014414	protein coding gene	Chr1:83459373-83588537 (+)
CAST/EiJ	ENSTCUGG00005053867	protein coding gene	Chr1:87462885-87582196 (+)
CBA/J	ENSMUSGG00210054523	protein coding gene	Chr1:87739122-87859648 (+)
DBA/2J	ENSMUSGG00185057730	protein coding gene	Chr1:92210266-92328870 (+)
FVB/NJ	ENSMUSGG00205054235	protein coding gene	Chr1:87151269-87273492 (+)
JF1/MsJ	ENSUMUGG00000058429	protein coding gene	Chr1:90953313-91072016 (+)
LP/J	ENSMUSG00230018340	protein coding gene	Chr1:91490023-91624010 (+)
NOD/ShiLtJ	ENSMUSGG00190054580	protein coding gene	Chr1:87791513-87910108 (+)
NZO/HlLtJ	ENSMUSG00225003614	protein coding gene	Chr1:95391417-95525402 (+)
PWK/PhJ	ENSLUMGG00010053818	protein coding gene	Chr1:87345805-87464496 (+)
SPRET/EiJ	ENSMSPG00010040511	protein coding gene	Chr1:89375568-89506497 (+)
WSB/EiJ	ENSIUOGG00005053896	protein coding gene	Chr1:87448664-87567133 (+)

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Human Ortholog

LRRFIP1, LRR binding FLII interacting protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRFIP1, LRR binding FLII interacting protein 1
Synonyms

FLAP-1, FLAP1, FLIIAP1, GCF-2, GCF2, HUFI-1, TRIP
Links

HGNC:6702

NCBI Gene ID: 9208

UniProt: Q32MZ4
Chr Location

2q37.3; chr2:237627554-237813682 (+) GRCh38

MGI Vertebrate Homology

Lrrfip1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LRRFIP1
Gene Tree

Lrrfip1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Lrrfip1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

683
Tissues

45
cDNA Data

152
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrfip1

ZFIN lrrfip1a, lrrfip1b

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All Sequences

164
RefSeq

88
UniProt

10
CCDS

CCDS35662.1, CCDS48319.1, CCDS48320.1, CCDS78647.1

Ensembl

ENSMUSG00000026305 (Evidence)
NCBI Gene

16978

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000026305	Ensembl Gene Model \| MGI Sequence Detail	130208	C57BL/6J	± kb
	transcript	ENSMUST00000097649	Ensembl \| MGI Sequence Detail	3645	Not Applicable
	polypeptide	ENSMUSP00000095254	Ensembl \| MGI Sequence Detail	729	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000009942 leucine-rich repeat flightless-interacting protein 1

(term hierarchy)
InterPro Domains

IPR019139 Leucine-rich repeat flightless-interacting protein 1/2
GlyGen

Q3UZ39 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 156

Genomic 1

cDNA 152

Primer pair 3

Microarray probesets 7

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MGI:1277983, MGI:2138480

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Summaries

All 51

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lrrfip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8024	Chr1:90926444-90926518 (+)	22 bp
Tssr8025	Chr1:90950444-90950449 (+)	23,988 bp
Tssr8026	Chr1:90972142-90972159 (+)	45,692 bp
Tssr8027	Chr1:90972172-90972184 (+)	45,719 bp
Tssr8028	Chr1:90972187-90972202 (+)	45,736 bp
Tssr8029	Chr1:90972208-90972220 (+)	45,755 bp
Tssr8030	Chr1:90977248-90977258 (+)	50,794 bp
Tssr8031	Chr1:90977405-90977427 (+)	50,957 bp
Tssr8032	Chr1:90980896-90980914 (+)	54,446 bp
Tssr8033	Chr1:90981144-90981242 (+)	54,734 bp
Tssr8034	Chr1:90981244-90981254 (+)	54,790 bp
Tssr8035	Chr1:90981267-90981272 (+)	54,811 bp
Tssr8036	Chr1:90981273-90981284 (+)	54,820 bp
Tssr8037	Chr1:90981695-90981714 (+)	55,246 bp
Tssr8038	Chr1:90984311-90984319 (+)	57,856 bp
Tssr8039	Chr1:90984344-90984358 (+)	57,892 bp
Tssr8040	Chr1:90984369-90984390 (+)	57,921 bp
Tssr8041	Chr1:90984395-90984418 (+)	57,948 bp
Tssr8042	Chr1:90985610-90985620 (+)	59,156 bp
Tssr8043	Chr1:90985655-90985665 (+)	59,201 bp
Tssr8044	Chr1:90990460-90990473 (+)	64,008 bp
Tssr8045	Chr1:90996269-90996296 (+)	69,824 bp
Tssr8046	Chr1:91001422-91001427 (+)	74,966 bp
Tssr8047	Chr1:91011205-91011209 (+)	84,748 bp
Tssr8048	Chr1:91021246-91021258 (+)	94,793 bp
Tssr8049	Chr1:91021283-91021290 (+)	94,828 bp
Tssr8050	Chr1:91035029-91035040 (+)	108,576 bp
Tssr8051	Chr1:91042516-91042528 (+)	116,063 bp
Tssr8052	Chr1:91043015-91043032 (+)	116,565 bp
Tssr8053	Chr1:91044384-91044409 (+)	117,938 bp
Tssr8054	Chr1:91049456-91049469 (+)	123,004 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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