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Lrrfip1 Gene Detail
Summary
  • Symbol
    Lrrfip1
  • Name
    leucine rich repeat (in FLII) interacting protein 1
  • Synonyms
    FLAP (FLI LRR associated protein), Fliiap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342770
    NCBI Gene: 16978
  • Alliance
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:90926459-91056666 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 46.03 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1641 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342770
protein coding gene Chr1:90924652-91056666 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016300
protein coding gene Chr1:92524047-92660821 (+)
A/J MGP_AJ_G0016281
protein coding gene Chr1:89189676-89324488 (+)
AKR/J MGP_AKRJ_G0016242
protein coding gene Chr1:91847977-91984933 (+)
BALB/cJ MGP_BALBcJ_G0016237
protein coding gene Chr1:89374442-89511555 (+)
C3H/HeJ MGP_C3HHeJ_G0016066
protein coding gene Chr1:92058452-92194424 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016696
protein coding gene Chr1:96083684-96220775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014414
protein coding gene Chr1:83459373-83588537 (+)
CAST/EiJ MGP_CASTEiJ_G0015651
protein coding gene Chr1:91384884-91527224 (+)
CBA/J MGP_CBAJ_G0016042
protein coding gene Chr1:99150799-99293393 (+)
DBA/2J MGP_DBA2J_G0016145
protein coding gene Chr1:88423091-88553053 (+)
FVB/NJ MGP_FVBNJ_G0016144
protein coding gene Chr1:87446602-87583084 (+)
LP/J MGP_LPJ_G0016216
protein coding gene Chr1:93687801-93826112 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016169
protein coding gene Chr1:102408245-102548758 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016736
protein coding gene Chr1:91869349-92006609 (+)
PWK/PhJ MGP_PWKPhJ_G0015435
protein coding gene Chr1:87832137-87965716 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015218
protein coding gene Chr1:90789983-90925382 (+)
WSB/EiJ MGP_WSBEiJ_G0015709
protein coding gene Chr1:91657082-91795268 (+)



Homology
more
  • Human Ortholog
    LRRFIP1, LRR binding FLII interacting protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRFIP1, LRR binding FLII interacting protein 1
  • Synonyms
    FLAP1, FLAP-1, FLIIAP1, GCF2, GCF-2, HUFI-1, TRIP
  • Links
    NCBI Gene ID: 9208
    neXtProt AC: NX_Q32MZ4
    UniProt: Q32MZ4

  • Chr Location
    2q37.3; chr2:237627587-237813682 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026305 Ensembl Gene Model | MGI Sequence Detail 130208 C57BL/6J ±  kb
transcript ENSMUST00000097649 Ensembl | MGI Sequence Detail 3645 Not Applicable  
polypeptide ENSMUSP00000095254 Ensembl | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000009942 leucine-rich repeat flightless-interacting protein 1
  • InterPro Domains
    IPR019139 Leucine-rich repeat flightless-interacting protein 1/2
Molecular
Reagents
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  • All nucleic 156
    Genomic 1
    cDNA 152
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGI:1277983, MGI:2138480
References
more
  • Summaries
    All 47
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory