Celf1 MGI Mouse Gene Detail - MGI:1342295 - CUGBP, Elav-like family member 1

Symbol

Celf1
Name

CUGBP, Elav-like family member 1
Synonyms

1600010O03Rik, Brunol2, CUG-BP, Cugbp1, CUG-BP1, D2Wsu101e

Feature Type

protein coding gene
IDs

MGI:1342295
NCBI Gene: 13046
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:90770727-90849842 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.44 cM
Mapping Data

4 experiments

SNPs within 2kb

1357 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1342295	protein coding gene	Chr2:90770604-90849842 (+)
129S1/SvImJ	ENSMUSG00200052536	protein coding gene	Chr2:87686217-87765420 (+)
A/J	ENSMUSG00195049123	protein coding gene	Chr2:87812029-87891779 (+)
AKR/J	ENSMUSG00220046940	protein coding gene	Chr2:87615980-87695123 (+)
BALB/cJ	ENSMUSG00180054791	protein coding gene	Chr2:87712251-87792000 (+)
C3H/HeJ	ENSMUSG00175053202	protein coding gene	Chr2:87981977-88061121 (+)
C57BL/6NJ	ENSMUSG00215051211	protein coding gene	Chr2:87813387-87892526 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023949	protein coding gene	Chr2:85065916-85144646 (+)
CAST/EiJ	ENSTCUG00005050827	protein coding gene	Chr2:87222809-87302083 (+)
CBA/J	ENSMUSG00210036156	protein coding gene	Chr2:87993151-88072297 (+)
DBA/2J	ENSMUSG00185056222	protein coding gene	Chr2:87708706-87788438 (+)
FVB/NJ	ENSMUSG00205051092	protein coding gene	Chr2:87006206-87085424 (+)
JF1/MsJ	ENSUMUG00000012309	protein coding gene	Chr2:87528655-87606961 (+)
LP/J	ENSMUSG00230036750	protein coding gene	Chr2:89459399-89539132 (+)
NOD/ShiLtJ	ENSMUSG00190046714	protein coding gene	Chr2:87787384-87867214 (+)
NZO/HlLtJ	ENSMUSG00225049490	protein coding gene	Chr2:97380905-97460743 (+)
PWK/PhJ	ENSLUMG00010046665	protein coding gene	Chr2:87515626-87595525 (+)
SPRET/EiJ	ENSMSPG00010052022	protein coding gene	Chr2:89474166-89551207 (+)
WSB/EiJ	ENSIUOG00005053303	protein coding gene	Chr2:87515305-87595057 (+)

Human Ortholog

CELF1, CUGBP Elav-like family member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CELF1, CUGBP Elav-like family member 1
Synonyms

BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, hNab50, NAB50, NAPOR
Links

HGNC:2549

NCBI Gene ID: 10658

UniProt: Q92879
Chr Location

11p11.2; chr11:47465933-47565569 (-) GRCh38

MGI Vertebrate Homology

Celf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CELF1
Gene Tree

Celf1

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

168
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

155
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Celf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

148 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous disruption of this gene results in significant postnatal lethality, growth retardation, and impaired fertility in both sexes. Male infertility is caused by a blockage of spermiogenesis at stage 7 and increased germ cell apoptosis but is not fully penetrant.

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All GO Annotations

57
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

788
Tissues

110
cDNA Data

29
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CELF1

Xenbase celf1

ZFIN celf1

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All Sequences

172
RefSeq

70
UniProt

2
CCDS

CCDS16420.1, CCDS16421.1

Ensembl

ENSMUSG00000005506 (Evidence)
NCBI Gene

13046

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005506	Ensembl Gene Model \| MGI Sequence Detail	79116	C57BL/6J	± kb
transcript	ENSMUST00000005643	Ensembl \| MGI Sequence Detail	4830	Not Applicable
polypeptide	ENSMUSP00000005643	Ensembl \| MGI Sequence Detail	513	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003439 CUGBP Elav-like family member 1

(term hierarchy)
InterPro Domains

IPR034196 CELF1/2, RNA recognition motif 1

IPR034198 CELF1/2, RNA recognition motif 2

IPR034199 CELF1/2, RNA recognition motif 3

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

P28659 1 site, 1 O-linked glycan (1 site)

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All nucleic 40

Genomic 2

cDNA 30

Primer pair 6

Other 2

Antibodies 3

Microarray probesets 12

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MGD-MRK-34246, MGI:106552, MGI:1923754, MGI:2138743

Summaries

All 122

Developmental Gene Expression 18

Gene Ontology 16

Phenotypes 33
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Celf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18807	Chr2:90770811-90770868 (+)	113 bp
Tssr18808	Chr2:90795413-90795425 (+)	24,692 bp
Tssr18809	Chr2:90795431-90795453 (+)	24,715 bp
Tssr18811	Chr2:90817926-90817937 (+)	47,205 bp
Tssr18812	Chr2:90817948-90817957 (+)	47,226 bp
Tssr18813	Chr2:90847106-90847117 (+)	76,385 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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