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Hspa4 Gene Detail
Summary
  • Symbol
    Hspa4
  • Name
    heat shock protein family A (Hsp70) member 4
  • Synonyms
    70kDa, APG-2, Hsp110, Hsp70RY
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342292
    NCBI Gene: 15525
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:53150641-53191284 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 31.91 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    721 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342292
 protein coding gene Chr11:53150641-53191306 (-)
129S1/SvImJ ENSMUSG00200038964
 protein coding gene Chr11:50146311-50186951 (-)
A/J ENSMUSG00195032702
 protein coding gene Chr11:50083535-50124185 (-)
AKR/J ENSMUSG00220030667
 protein coding gene Chr11:50272428-50313072 (-)
BALB/cJ ENSMUSG00180035785
 protein coding gene Chr11:50144983-50185631 (-)
C3H/HeJ ENSMUSG00175032700
 protein coding gene Chr11:50114867-50155512 (-)
C57BL/6NJ ENSMUSG00215025598
 protein coding gene Chr11:49937640-49978290 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016329
 protein coding gene Chr11:48186799-48229252 (-)
CAST/EiJ ENSTCUG00005043157
 protein coding gene Chr11:49707354-49748569 (-)
CBA/J ENSMUSG00210026263
 protein coding gene Chr11:49970824-50011474 (-)
DBA/2J ENSMUSG00185024360
 protein coding gene Chr11:50182761-50223446 (-)
FVB/NJ ENSMUSG00205023845
 protein coding gene Chr11:50013137-50053788 (-)
JF1/MsJ ENSUMUG00000037341
 protein coding gene Chr11:50556324-50597642 (-)
LP/J ENSMUSG00230044808
 protein coding gene Chr11:51364002-51404645 (-)
NOD/ShiLtJ ENSMUSG00190033785
 protein coding gene Chr11:50241899-50282541 (-)
NZO/HlLtJ ENSMUSG00225032099
 protein coding gene Chr11:53404945-53445594 (-)
PWK/PhJ ENSLUMG00010032735
 protein coding gene Chr11:50007604-50048936 (-)
SPRET/EiJ ENSMSPG00010018483
 protein coding gene Chr11:50685512-50733414 (-)
WSB/EiJ ENSIUOG00005038913
 protein coding gene Chr11:50026431-50067105 (-)



Homology
more
  • Human Ortholog
    HSPA4, heat shock protein family A (Hsp70) member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA4, heat shock protein family A (Hsp70) member 4
  • Synonyms
    APG-2, HEL-S-5a, HS24/P52, hsp70, hsp70RY, HSPH2, RY
  • Links
    NCBI Gene ID: 3308
    UniProt: P34932

  • Chr Location
    5q31.1; chr5:133051946-133106449 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HSPA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit age-dependent neurofibrillary tangles and tau deposits, impaired contextual conditioning, and impaired bar grasping.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    17
  • cDNA Data
    25
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020361 Ensembl Gene Model | MGI Sequence Detail 40644 C57BL/6J ±  kb
    transcript ENSMUST00000020630 Ensembl | MGI Sequence Detail 4618 Not Applicable  
    polypeptide ENSMUSP00000020630 Ensembl | MGI Sequence Detail 842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000003414 heat shock 70 kDa protein 4
      (term hierarchy)
    • InterPro Domains
      IPR043129 ATPase, nucleotide binding domain
      IPR018181 Heat shock protein 70, conserved site
      IPR013126 Heat shock protein 70 family
      IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
      IPR042052 HSPA4, nucleotide-binding domain
      IPR060486 HYOU1-like, C-terminal domain
    • GlyGen
      Q61316 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 2
      cDNA 29

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1096373, MGI:2144116
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:369945 Elkenani M, et al., Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis. J Transl Med. 2022 May 14;20(1):229
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory