About   Help   FAQ
Slc25a17 Gene Detail
Summary
  • Symbol
    Slc25a17
  • Name
    solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
  • Synonyms
    34kDa, PMP34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342248
    NCBI Gene: 20524
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:81203122-81244966 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 38.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    249 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342248
 protein coding gene Chr15:81203112-81245013 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022109
 protein coding gene Chr15:81736386-81781420 (-)
A/J MGP_AJ_G0022070
 protein coding gene Chr15:78866831-78908518 (-)
AKR/J MGP_AKRJ_G0022045
 protein coding gene Chr15:81062388-81103896 (-)
BALB/cJ MGP_BALBcJ_G0022076
 protein coding gene Chr15:78892310-78937537 (-)
C3H/HeJ MGP_C3HHeJ_G0021847
 protein coding gene Chr15:81053826-81098654 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022519
 protein coding gene Chr15:84931970-84975460 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020049
 protein coding gene Chr15:75332283-75376250 (-)
CAST/EiJ MGP_CASTEiJ_G0021368
 protein coding gene Chr15:81808494-81852697 (-)
CBA/J MGP_CBAJ_G0021812
 protein coding gene Chr15:87584554-87631962 (-)
DBA/2J MGP_DBA2J_G0021941
 protein coding gene Chr15:78349019-78391259 (-)
FVB/NJ MGP_FVBNJ_G0021919
 protein coding gene Chr15:77388183-77431112 (-)
LP/J MGP_LPJ_G0022009
 protein coding gene Chr15:81889706-81939588 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021939
 protein coding gene Chr15:92564085-92608574 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022533
 protein coding gene Chr15:81121575-81166821 (-)
PWK/PhJ MGP_PWKPhJ_G0021110
 protein coding gene Chr15:78375741-78418784 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020947
 protein coding gene Chr15:80920691-80963352 (-)
WSB/EiJ MGP_WSBEiJ_G0021420
 protein coding gene Chr15:81547924-81594557 (-)



Homology
more
  • Human Ortholog
    SLC25A17, solute carrier family 25 member 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A17, solute carrier family 25 member 17
  • Synonyms
    PMP34
  • Links
    NCBI Gene ID: 10478
    neXtProt AC: NX_O43808
    UniProt: O43808

  • Chr Location
    22q13.2; chr22:40769630-40819399 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit background sensitive prenatal lethality and phytol-diet induced enlarged liver, hepatic steatosis, and liver apoptosis, and inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    23
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20524 NCBI Gene Model | MGI Sequence Detail 41845 C57BL/6J ±  kb
    transcript NM_011399 RefSeq | MGI Sequence Detail 1667 C57BL/6  
    polypeptide O70579 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:291257 Van Veldhoven PP, et al., Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid. Front Cell Dev Biol. 2020;8:144
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory