Msl3 MGI Mouse Gene Detail - MGI:1341851

Symbol

Msl3
Name

MSL complex subunit 3
Synonyms

Msl31, Msl3l1

Feature Type

protein coding gene
IDs

MGI:1341851
NCBI Gene: 17692
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:167437113-167456894 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 78.73 cM
Mapping Data

2 experiments

SNPs within 2kb

517 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1341851	protein coding gene	ChrX:167434263-167456894 (-)
129S1/SvImJ	ENSMUSG00200013713	protein coding gene	ChrX:144190419-144210214 (-)
A/J	ENSMUSG00195015774	protein coding gene	ChrX:149298596-149318392 (-)
AKR/J	ENSMUSG00220030053	protein coding gene	ChrX:141184652-141204448 (-)
BALB/cJ	ENSMUSG00180017670	protein coding gene	ChrX:144685139-144704940 (-)
C3H/HeJ	ENSMUSG00175010209	protein coding gene	ChrX:149231685-149251469 (-)
C57BL/6NJ	ENSMUSG00215015460	protein coding gene	ChrX:145057738-145077523 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033581	protein coding gene	ChrX:156712661-156736046 (-)
CAST/EiJ	ENSTCUG00005023683	protein coding gene	ChrX:146775964-146795769 (-)
CBA/J	ENSMUSG00210027465	protein coding gene	ChrX:146645355-146665140 (-)
DBA/2J	ENSMUSG00185030078	protein coding gene	ChrX:161499294-161519079 (-)
FVB/NJ	ENSMUSG00205002636	protein coding gene	ChrX:145154936-145174721 (-)
JF1/MsJ	ENSUMUG00000036132	protein coding gene	ChrX:181929896-181949755 (-)
LP/J	ENSMUSG00230025033	protein coding gene	ChrX:168291103-168310892 (-)
NOD/ShiLtJ	ENSMUSG00190021186	protein coding gene	ChrX:145662118-145681914 (-)
NZO/HlLtJ	ENSMUSG00225038017	protein coding gene	ChrX:171684482-171704264 (-)
PWK/PhJ	ENSLUMG00010001646	protein coding gene	ChrX:143002883-143022615 (-)
SPRET/EiJ	ENSMSPG00010025024	protein coding gene	ChrX:148321874-148341594 (-)
WSB/EiJ	ENSIUOG00005010945	protein coding gene	ChrX:146104727-146124495 (-)

Human Ortholog

MSL3, MSL complex subunit 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MSL3, MSL complex subunit 3
Synonyms

MRSXBA, MRXS36, MRXSBA, MSL3L1
Links

HGNC:7370

NCBI Gene ID: 10943

UniProt: Q8N5Y2
Chr Location

Xp22.2; chrX:11758159-11775772 (+) GRCh38

MGI Vertebrate Homology

Msl3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MSL3
Gene Tree

Msl3

Diseases

1 with human MSL3 associations

				Human Disease	Mouse Models
				Basilicata-Akhtar syndrome IDs Basilicata-Akhtar syndrome DOID:0111838 OMIM:301032

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

6
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

12 strains or lines available

less

All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

641
Tissues

26
cDNA Data

17
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase msl3

less

All Sequences

69
RefSeq

28
UniProt

1
CCDS

CCDS41211.1, CCDS90775.1

Ensembl

ENSMUSG00000031358 (Evidence)
NCBI Gene

17692

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031358	Ensembl Gene Model \| MGI Sequence Detail	19782	C57BL/6J	± kb
transcript	ENSMUST00000033725	Ensembl \| MGI Sequence Detail	2399	Not Applicable
polypeptide	ENSMUSP00000033725	Ensembl \| MGI Sequence Detail	525	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000010675 male-specific lethal 3

(term hierarchy)
InterPro Domains

IPR000953 Chromo/chromo shadow domain

IPR016197 Chromo-like domain superfamily

IPR008676 MRG

IPR038217 MRG, C-terminal domain superfamily

IPR026541 MRG domain

IPR053820 MSL3 chromodomain-like

less

All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 3

less

MGI:2147958

Summaries

All 44

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 10
Earliest

J:56272 Prakash SK, et al., Characterization of a novel chromo domain gene in xp22.3 with homology to Drosophila msl-3. Genomics. 1999 Jul 1;59(1):77-84
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Msl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164633	ChrX:167457345-167457357 (-)	-457 bp
Tssr164632	ChrX:167456824-167456892 (-)	36 bp
Tssr164631	ChrX:167456801-167456812 (-)	87 bp
Tssr164630	ChrX:167455524-167455560 (-)	1,352 bp
Tssr164629	ChrX:167455478-167455503 (-)	1,403 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24