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Dapk2 Gene Detail
Summary
  • Symbol
    Dapk2
  • Name
    death-associated protein kinase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341297
    NCBI Gene: 13143
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:66065505-66179524 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 35.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3429 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341297
protein coding gene Chr9:66065364-66179524 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034974
protein coding gene Chr9:65966431-66090087 (+)
A/J MGP_AJ_G0034954
protein coding gene Chr9:63707687-63823024 (+)
AKR/J MGP_AKRJ_G0034884
protein coding gene Chr9:65226077-65347980 (+)
BALB/cJ MGP_BALBcJ_G0034947
protein coding gene Chr9:63422272-63538288 (+)
C3H/HeJ MGP_C3HHeJ_G0034657
protein coding gene Chr9:65755495-65878148 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035466
protein coding gene Chr9:67755050-67898363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032377
protein coding gene Chr9:63361605-63474620 (+)
CAST/EiJ MGP_CASTEiJ_G0033978
protein coding gene Chr9:65952847-66078386 (+)
CBA/J MGP_CBAJ_G0034628
protein coding gene Chr9:70110590-70238022 (+)
DBA/2J MGP_DBA2J_G0034787
protein coding gene Chr9:63483531-63602586 (+)
FVB/NJ MGP_FVBNJ_G0034729
protein coding gene Chr9:62823917-62940789 (+)
LP/J MGP_LPJ_G0034870
protein coding gene Chr9:66219174-66348511 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034771
protein coding gene Chr9:71350809-71475351 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035488
protein coding gene Chr9:65335040-65451202 (+)
PWK/PhJ MGP_PWKPhJ_G0033682
protein coding gene Chr9:63682343-63800680 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033516
protein coding gene Chr9:65624333-65746585 (+)
WSB/EiJ MGP_WSBEiJ_G0034091
protein coding gene Chr9:65232766-65353561 (+)



Homology
more
  • Human Ortholog
    DAPK2, death associated protein kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DAPK2, death associated protein kinase 2
  • Synonyms
    DRP-1, DRP1
  • Links
    NCBI Gene ID: 23604
    neXtProt AC: NX_Q9UIK4
    UniProt: Q9UIK4

  • Chr Location
    15q22.31; chr15:63907036-64072033 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032380 Ensembl Gene Model | MGI Sequence Detail 114020 C57BL/6J ±  kb
transcript ENSMUST00000238682 Ensembl | MGI Sequence Detail 1594 Not Applicable  
polypeptide ENSMUSP00000158747 Ensembl | MGI Sequence Detail 490 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:55856 Kawai T, et al., Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene. 1999 Jun 10;18(23):3471-80
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2024
MGI 6.24
The Jackson Laboratory