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Fcna Gene Detail
Summary
  • Symbol
    Fcna
  • Name
    ficolin A
  • Synonyms
    Fcn1, ficolin A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340905
    NCBI Gene: 14133
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25514678-25518042 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.58 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340905
 protein coding gene Chr2:25514677-25525448 (-)
129S1/SvImJ ENSMUSG00200049325
 protein coding gene Chr2:22498831-22502197 (-)
A/J ENSMUSG00195043574
 protein coding gene Chr2:22588914-22592277 (-)
AKR/J ENSMUSG00220048816
 protein coding gene Chr2:22706742-22710105 (-)
BALB/cJ ENSMUSG00180054250
 protein coding gene Chr2:22600492-22603858 (-)
C3H/HeJ ENSMUSG00175047753
 protein coding gene Chr2:22564639-22568003 (-)
C57BL/6NJ ENSMUSG00215042315
 protein coding gene Chr2:22623380-22626744 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023289
 protein coding gene Chr2:21523417-21526818 (-)
CAST/EiJ ENSTCUG00005050762
 protein coding gene Chr2:22349590-22352931 (-)
CBA/J ENSMUSG00210016717
 protein coding gene Chr2:22603617-22606981 (-)
DBA/2J ENSMUSG00185051332
 protein coding gene Chr2:22503092-22506455 (-)
FVB/NJ ENSMUSG00205047711
 protein coding gene Chr2:22357453-22360817 (-)
JF1/MsJ ENSUMUG00000026303
 protein coding gene Chr2:22423395-22426728 (-)
LP/J ENSMUSG00230041712
 protein coding gene Chr2:24434813-24438177 (-)
NOD/ShiLtJ ENSMUSG00190050044
 protein coding gene Chr2:22593961-22597324 (-)
NZO/HlLtJ ENSMUSG00225009009
 protein coding gene Chr2:32185247-32188610 (-)
PWK/PhJ ENSLUMG00010044477
 protein coding gene Chr2:22520325-22523662 (-)
SPRET/EiJ ENSMSPG00010034796
 protein coding gene Chr2:23201261-23204644 (-)
WSB/EiJ ENSIUOG00005051378
 protein coding gene Chr2:22461006-22464368 (-)



Homology
more
  • Human Ortholog
    FCN1, ficolin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCN1, ficolin 1
  • Synonyms
    FCNM
  • Links
    NCBI Gene ID: 2219
    UniProt: O00602

  • Chr Location
    9q34.3; chr9:134903232-134917954 (-)  GRCh38
  • Human Ortholog
    FCN2, ficolin 2
  • Synonyms
    EBP-37, FCNL, ficolin-2, P35
  • Links
    NCBI Gene ID: 2220
    UniProt: Q15485

  • Chr Location
    9q34.3; chr9:134864144-134890508 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal collagen antibody-induced arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    22
  • cDNA Data
    43
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026938 Ensembl Gene Model | MGI Sequence Detail 3365 C57BL/6J ±  kb
transcript ENSMUST00000028307 Ensembl | MGI Sequence Detail 1374 Not Applicable  
polypeptide ENSMUSP00000028307 Ensembl | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 43
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1270842
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:46796 Fujimori Y, et al., Molecular cloning and characterization of mouse ficolin-A. Biochem Biophys Res Commun. 1998 Mar 27;244(3):796-800
  • Latest
    J:348350 Zhu LW, et al., Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1. Cell Commun Signal. 2024 May 15;22(1):271
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory