Ftcd MGI Mouse Gene Detail - MGI:1339962 - formiminotransferase cyclodeaminase

About Help FAQ

Ftcd Gene Detail

Symbol

Ftcd
Name

formiminotransferase cyclodeaminase
Synonyms

glutamate formiminotransferase

Feature Type

protein coding gene
IDs

MGI:1339962
NCBI Gene: 14317
Alliance

genome feature page
Transcription Start Sites

5 TSS
Candidate for QTL

3 QTL

more

Sequence Map

Chr10:76411482-76426172 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.25 cM
Mapping Data

4 experiments

more

SNPs within 2kb

521 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1339962	protein coding gene	Chr10:76411482-76426172 (+)
129S1/SvImJ	ENSMUSG00200041645	protein coding gene	Chr10:73088626-73102885 (+)
A/J	ENSMUSG00195042268	protein coding gene	Chr10:73425248-73439487 (+)
AKR/J	ENSMUSG00220040142	protein coding gene	Chr10:73084957-73099200 (+)
BALB/cJ	ENSMUSG00180052459	protein coding gene	Chr10:73439704-73453948 (+)
C3H/HeJ	ENSMUSG00175042236	protein coding gene	Chr10:73310966-73325209 (+)
C57BL/6NJ	ENSMUSG00215052041	protein coding gene	Chr10:73048616-73062868 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015472	protein coding gene	Chr10:70614267-70628998 (+)
CAST/EiJ	ENSTCUG00005047856	protein coding gene	Chr10:72938197-72952122 (+)
CBA/J	ENSMUSG00210046094	protein coding gene	Chr10:73167172-73181422 (+)
DBA/2J	ENSMUSG00185048368	protein coding gene	Chr10:73509427-73523705 (+)
FVB/NJ	no annotation
JF1/MsJ	ENSUMUG00000043385	protein coding gene	Chr10:74659665-74673817 (+)
LP/J	ENSMUSG00230044420	protein coding gene	Chr10:75278986-75293243 (+)
NOD/ShiLtJ	ENSMUSG00190045450	protein coding gene	Chr10:73486941-73501188 (+)
NZO/HlLtJ	ENSMUSG00225046403	protein coding gene	Chr10:79575682-79589918 (+)
PWK/PhJ	ENSLUMG00010049779	protein coding gene	Chr10:73050470-73064509 (+)
SPRET/EiJ	ENSMSPG00010038815	protein coding gene	Chr10:74840584-74854700 (+)
WSB/EiJ	ENSIUOG00005045328	protein coding gene	Chr10:73091698-73106044 (+)

more

Human Ortholog

FTCD, formimidoyltransferase cyclodeaminase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FTCD, formimidoyltransferase cyclodeaminase
Synonyms

LCHC1
Links

HGNC:3974

NCBI Gene ID: 10841

UniProt: O95954
Chr Location

21q22.3; chr21:46136083-46155581 (-) GRCh38

MGI Vertebrate Homology

Ftcd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FTCD
Gene Tree

Ftcd

more

Diseases

1 with human FTCD associations

				Human Disease	Mouse Models
				glutamate formiminotransferase deficiency IDs glutamate formiminotransferase deficiency DOID:0111679 MESH:C537425 OMIM:229100 ORDO:51208 UMLS_CUI:C0268609

Click on a disease name to see all genes associated with that disease.

References

2 with disease annotations

less

Phenotype Summary

43 phenotype references

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

10
Targeted

6
Genomic Mutations

5 involving Ftcd
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

less

All GO Annotations

44
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

136
cDNA Data

41
Literature Summary

8

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ftcd

ZFIN ftcd

less

All Sequences

45
RefSeq

6
UniProt

1
CCDS

CCDS23950.1

Ensembl

ENSMUSG00000001155 (Evidence)
NCBI Gene

14317

Representative Sequences				Length	Strain/Species	Flank
	genomic	14317	NCBI Gene Model \| MGI Sequence Detail	14691	C57BL/6J	± kb
	transcript	NM_080845	RefSeq \| MGI Sequence Detail	2710	ZRU/MplStud
	polypeptide	Q91XD4	UniProt \| EBI \| MGI Sequence Detail	541	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000007689 formimidoyltransferase-cyclodeaminase

(term hierarchy)
EC

2.1.2.5, 4.3.1.4
InterPro Domains

IPR007044 Cyclodeaminase/cyclohydrolase

IPR036178 Formimidoyltransferase-cyclodeaminase-like superfamily

IPR004227 Formiminotransferase catalytic domain

IPR022384 Formiminotransferase catalytic domain superfamily

IPR013802 Formiminotransferase, C-terminal subdomain

IPR037070 Formiminotransferase, C-terminal subdomain superfamily

IPR051623 Formiminotransferase-cyclodeaminase

IPR012886 Formiminotransferase, N-terminal subdomain

IPR037064 Formiminotransferase, N-terminal subdomain superfamily
GlyGen

Q91XD4 1 site, 1 O-linked glycan (1 site)

less

All nucleic 45

Genomic 1

cDNA 41

Primer pair 3

Antibodies 1

Microarray probesets 3

more

Summaries

All 87

Developmental Gene Expression 8

Diseases 2

Gene Ontology 12

Phenotypes 43
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Ftcd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94190	Chr10:76411474-76411490 (+)	0 bp
Tssr94191	Chr10:76412232-76412253 (+)	761 bp
Tssr94192	Chr10:76417369-76417380 (+)	5,893 bp
Tssr94193	Chr10:76419709-76419716 (+)	8,231 bp
Tssr94194	Chr10:76419726-76419734 (+)	8,248 bp

Ftcd is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bgeq8	Chr10, 66.75 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Igfbp3q2	Chr10, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.
Insq9	Chr10, 39.72 cM	Chr10:82490938-82491121	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Bgeq8 (57 cM) on mouse Chromosome 10 as identified by ExQuest are Rdh7 and Hsd17b9. Hsd17b9 exhibits 9.5-fold increased expression in the liver of Tally Ho compared to C57BL/6J animals. For QTLs Insq9 (44 cM) and Igfbp3q2 (46 cM), potential candidate genes Ass1 (20 cM Chr 2)), Ftcd, Col18a1 (41.3 cM), Itgb2 (41.5 cM), Agpat3 (41.8 cM), Ndufs7, Oaz1 (43 cM), Pah (47 cM), Igf1 (48 cM), Nr1h4 (50 cM), and Kitl (57 cM) were identified.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24