S100a6 MGI Mouse Gene Detail - MGI:1339467 - S100 calcium binding protein A6 (calcyclin)

Symbol

S100a6
Name

S100 calcium binding protein A6 (calcyclin)
Synonyms

2A9, 5B10, Cacy, CALCYCLIN, PRA

Feature Type

protein coding gene
IDs

MGI:1339467
NCBI Gene: 20200
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr3:90520189-90531488 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.35 cM, cytoband F1-F2
Mapping Data

18 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339467	protein coding gene	Chr3:90520189-90531797 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027477	protein coding gene	Chr3:90945874-90959738 (+)
A/J	MGP_AJ_G0027441	protein coding gene	Chr3:87909523-87920867 (+)
AKR/J	MGP_AKRJ_G0027406	protein coding gene	Chr3:90075496-90086767 (+)
BALB/cJ	MGP_BALBcJ_G0027450	protein coding gene	Chr3:87866518-87877921 (+)
C3H/HeJ	MGP_C3HHeJ_G0027192	protein coding gene	Chr3:90237212-90248505 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027896	protein coding gene	Chr3:94349446-94363626 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025249	protein coding gene	Chr3:83411530-83423209 (+)
CAST/EiJ	MGP_CASTEiJ_G0026638	protein coding gene	Chr3:90634488-90646778 (+)
CBA/J	MGP_CBAJ_G0027167	protein coding gene	Chr3:97555794-97569348 (+)
DBA/2J	MGP_DBA2J_G0027304	protein coding gene	Chr3:87274786-87287109 (+)
FVB/NJ	MGP_FVBNJ_G0027272	protein coding gene	Chr3:85605218-85616617 (+)
LP/J	MGP_LPJ_G0027413	protein coding gene	Chr3:92001833-92016584 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027293	protein coding gene	Chr3:103798685-103821149 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027955	protein coding gene	Chr3:89823016-89835220 (+)
PWK/PhJ	MGP_PWKPhJ_G0026372	protein coding gene	Chr3:87174398-87186434 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026192	protein coding gene	Chr3:89003789-89015051 (+)
WSB/EiJ	MGP_WSBEiJ_G0026720	protein coding gene	Chr3:90228883-90241624 (+)

Human Ortholog

S100A6, S100 calcium binding protein A6

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

S100A6, S100 calcium binding protein A6
Synonyms

2A9, 5B10, CABP, CACY, PRA, S10A6
Links

HGNC:10496

NCBI Gene ID: 6277

neXtProt AC: NX_P06703

UniProt: P06703
Chr Location

1q21.3; chr1:153534599-153536244 (-) GRCh38

MGI Vertebrate Homology

S100a6 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: S100A6
Gene Tree

S100a6

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving S100a6
Find Mice (IMSR)

13 strains or lines available

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

62
cDNA Data

167
Literature Summary

22

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

66
RefSeq

23
UniProt

2
CCDS

CCDS38506.1

Ensembl

ENSMUSG00000001025 (Evidence)
NCBI Gene

20200

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001025	Ensembl Gene Model \| MGI Sequence Detail	11300	C57BL/6J	± kb
transcript	ENSMUST00000001051	Ensembl \| MGI Sequence Detail	731	Not Applicable
polypeptide	ENSMUSP00000001051	Ensembl \| MGI Sequence Detail	89	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014413 protein S100-A6

(term hierarchy)
PDB

4P2Y
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR034118 Protein S100-A6

IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

IPR001751 S100/Calcium binding protein 7/8-like, conserved site

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All nucleic 175

Genomic 3

cDNA 170

Primer pair 2

Microarray probesets 3

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MGD-MRK-1721, MGI:88241

Summaries

All 98

Developmental Gene Expression 22

Diseases 1

Gene Ontology 12

Phenotypes 13
Earliest

J:15754 Edwards DR, et al., Transcriptional regulation of two serum-induced RNAs in mouse fibroblasts: equivalence of one species to B2 repetitive elements. Mol Cell Biol. 1985 Nov;5(11):3280-8
Latest

J:335193 Derk J, et al., Formation and function of the meningeal arachnoid barrier around the developing mouse brain. Dev Cell. 2023 Apr 24;58(8):635-644.e4

TSS for S100a6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30242	Chr3:90519579-90519603 (+)	-598 bp
Tssr30243	Chr3:90520139-90520172 (+)	-33 bp
Tssr30244	Chr3:90520176-90520188 (+)	-7 bp
Tssr30245	Chr3:90520207-90520286 (+)	58 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23