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Ctsw Gene Detail
Summary
  • Symbol
    Ctsw
  • Name
    cathepsin W
  • Synonyms
    lymphopain
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338045
    NCBI Gene: 13041
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5515071-5518535 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.33 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338045
 protein coding gene Chr19:5515071-5518558 (-)
129S1/SvImJ ENSMUSG00200046743
 protein coding gene Chr19:2276516-2280453 (-)
A/J ENSMUSG00195042878
 protein coding gene Chr19:2670857-2674792 (-)
AKR/J ENSMUSG00220041380
 protein coding gene Chr19:2443980-2447915 (-)
BALB/cJ ENSMUSG00180049767
 protein coding gene Chr19:3045577-3049512 (-)
C3H/HeJ ENSMUSG00175009976
 protein coding gene Chr19:2295792-2299727 (-)
C57BL/6NJ ENSMUSG00215039258
 protein coding gene Chr19:2514719-2518656 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022552
 protein coding gene Chr19:2202485-2205766 (-)
CAST/EiJ ENSTCUG00005042447
 protein coding gene Chr19:2435536-2439490 (-)
CBA/J ENSMUSG00210048808
 protein coding gene Chr19:2298087-2302024 (-)
DBA/2J ENSMUSG00185045886
 protein coding gene Chr19:2674548-2678485 (-)
FVB/NJ ENSMUSG00205046185
 protein coding gene Chr19:2681681-2685617 (-)
JF1/MsJ ENSUMUG00000014930
 protein coding gene Chr19:2652345-2656297 (-)
LP/J ENSMUSG00230052561
 protein coding gene Chr19:3583423-3587360 (-)
NOD/ShiLtJ ENSMUSG00190050218
 protein coding gene Chr19:2204349-2209307 (-)
NZO/HlLtJ ENSMUSG00225026574
 protein coding gene Chr19:7292193-7296130 (-)
PWK/PhJ ENSLUMG00010003327
 protein coding gene Chr19:2420958-2424910 (-)
SPRET/EiJ ENSMSPG00010046866
 protein coding gene Chr19:2410144-2414920 (-)
WSB/EiJ ENSIUOG00005050593
 protein coding gene Chr19:2313520-2317457 (-)



Homology
more
  • Human Ortholog
    CTSW, cathepsin W
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSW, cathepsin W
  • Synonyms
    LYPN
  • Links
    NCBI Gene ID: 1521
    UniProt: P56202

  • Chr Location
    11q13.1; chr11:65879809-65883741 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Homozygous null mutants are fertile and healthy with normal cytotoxic lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    1
  • cDNA Data
    21
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024910 Ensembl Gene Model | MGI Sequence Detail 3465 C57BL/6J ±  kb
transcript ENSMUST00000025844 Ensembl | MGI Sequence Detail 1241 Not Applicable  
polypeptide ENSMUSP00000025844 Ensembl | MGI Sequence Detail 371 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 1
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:50847 Brown J, et al., Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. Leukemia. 1998 Nov;12(11):1771-81
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory