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Tfg Gene Detail
Summary
  • Symbol
    Tfg
  • Name
    Trk-fused gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338041
    NCBI Gene: 21787
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:56510695-56537813 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 34.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    815 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338041
 protein coding gene Chr16:56510692-56541801 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022890
 protein coding gene Chr16:55823863-55852134 (-)
A/J MGP_AJ_G0022857
 protein coding gene Chr16:53421058-53448173 (-)
AKR/J MGP_AKRJ_G0022829
 protein coding gene Chr16:55111382-55138499 (-)
BALB/cJ MGP_BALBcJ_G0022857
 protein coding gene Chr16:53525433-53552550 (-)
C3H/HeJ MGP_C3HHeJ_G0022620
 protein coding gene Chr16:55303436-55330553 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023305
 protein coding gene Chr16:57411303-57440615 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020816
 protein coding gene Chr16:53102214-53129750 (-)
CAST/EiJ MGP_CASTEiJ_G0022147
 protein coding gene Chr16:55660967-55722574 (-)
CBA/J MGP_CBAJ_G0022593
 protein coding gene Chr16:59699357-59728144 (-)
DBA/2J MGP_DBA2J_G0022725
 protein coding gene Chr16:53181863-53209232 (-)
FVB/NJ MGP_FVBNJ_G0022700
 protein coding gene Chr16:52947319-52974546 (-)
LP/J MGP_LPJ_G0022792
 protein coding gene Chr16:55640487-55667533 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022718
 protein coding gene Chr16:60027439-60068442 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023320
 protein coding gene Chr16:55286339-55314708 (-)
PWK/PhJ MGP_PWKPhJ_G0021886
 protein coding gene Chr16:53468062-53531147 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021716
 protein coding gene Chr16:54999869-55061456 (-)
WSB/EiJ MGP_WSBEiJ_G0022191
 protein coding gene Chr16:55308065-55335162 (-)



Homology
more
  • Human Ortholog
    TFG, trafficking from ER to golgi regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFG, trafficking from ER to golgi regulator
  • Synonyms
    HMSNP, SPG57, TF6, TRKT3
  • Links
    NCBI Gene ID: 10342
    UniProt: Q92734

  • Chr Location
    3q12.2; chr3:100709290-100748967 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TFG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    25
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022757 Ensembl Gene Model | MGI Sequence Detail 27119 C57BL/6J ±  kb
    transcript ENSMUST00000065515 Ensembl | MGI Sequence Detail 1945 Not Applicable  
    polypeptide ENSMUSP00000067867 Ensembl | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146382
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Phenotypes 16
    • Earliest
      J:54190 Mencinger M, et al., Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73
    • Latest
      J:384727 Steinmetz TD, et al., Identification of TFG- and Autophagy-Regulated Proteins and Glycerophospholipids in B Cells. J Proteome Res. 2024 May 3;23(5):1615-1633
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/09/2026
    MGI 6.24     		The Jackson Laboratory