Gdap2 MGI Mouse Gene Detail - MGI:1338001 - ganglioside-induced differentiation-associated-protein 2

Symbol

Gdap2
Name

ganglioside-induced differentiation-associated-protein 2
Synonyms

D3Ertd801e

Feature Type

protein coding gene
IDs

MGI:1338001
NCBI Gene: 14547
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:100069697-100114297 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 43.49 cM
Mapping Data

3 experiments

SNPs within 2kb

379 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338001	protein coding gene	Chr3:100069697-100117909 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027666	protein coding gene	Chr3:101283121-101330679 (+)
A/J	MGP_AJ_G0027625	protein coding gene	Chr3:98063850-98112325 (+)
AKR/J	MGP_AKRJ_G0027591	protein coding gene	Chr3:100438817-100485996 (+)
BALB/cJ	MGP_BALBcJ_G0027638	protein coding gene	Chr3:97841498-97886359 (+)
C3H/HeJ	MGP_C3HHeJ_G0027367	protein coding gene	Chr3:100757519-100803538 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028081	protein coding gene	Chr3:105002587-105048533 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025422	protein coding gene	Chr3:94290089-94334920 (+)
CAST/EiJ	MGP_CASTEiJ_G0026823	protein coding gene	Chr3:99873313-99919314 (+)
CBA/J	MGP_CBAJ_G0027342	protein coding gene	Chr3:108622803-108668443 (+)
DBA/2J	MGP_DBA2J_G0027485	protein coding gene	Chr3:97312756-97359351 (+)
FVB/NJ	MGP_FVBNJ_G0027453	protein coding gene	Chr3:95266233-95311126 (+)
LP/J	MGP_LPJ_G0027592	protein coding gene	Chr3:102621023-102670612 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0028136	protein coding gene	Chr3:99943272-99993146 (+)
PWK/PhJ	MGP_PWKPhJ_G0026550	protein coding gene	Chr3:97068947-97114438 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026372	protein coding gene	Chr3:98064012-98113239 (+)
WSB/EiJ	MGP_WSBEiJ_G0026903	protein coding gene	Chr3:100523082-100567252 (+)

Human Ortholog

GDAP2, ganglioside induced differentiation associated protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GDAP2, ganglioside induced differentiation associated protein 2
Synonyms

MACROD3, SCAR27
Links

HGNC:18010

NCBI Gene ID: 54834

neXtProt AC: NX_Q9NXN4

UniProt: Q9NXN4
Chr Location

1p12; chr1:117863485-117929621 (-) GRCh38

MGI Vertebrate Homology

Gdap2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GDAP2
Gene Tree

Gdap2

Diseases

1 with human GDAP2 associations

				Human Disease	Mouse Models
				autosomal recessive spinocerebellar ataxia 27 IDs autosomal recessive spinocerebellar ataxia 27 DOID:0111616 OMIM:618369

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Gdap2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

834
Tissues

30
cDNA Data

59
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gdap2

less

All Sequences

63
RefSeq

11
UniProt

2
CCDS

CCDS17675.1

Ensembl

ENSMUSG00000027865 (Evidence)
NCBI Gene

14547

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027865	Ensembl Gene Model \| MGI Sequence Detail	44601	C57BL/6J	± kb
transcript	ENSMUST00000106997	Ensembl \| MGI Sequence Detail	2014	Not Applicable
polypeptide	ENSMUSP00000102610	Ensembl \| MGI Sequence Detail	546	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000007914 ganglioside-induced differentiation-associated protein 2

(term hierarchy)
InterPro Domains

IPR001251 CRAL-TRIO lipid binding domain

IPR036865 CRAL-TRIO lipid binding domain superfamily

IPR035793 GDAP2, macro domain

IPR002589 Macro domain

IPR043472 Macro domain-like

less

All nucleic 61

cDNA 59

Primer pair 2

Microarray probesets 3

less

MGI:1289278, MGI:2140042

Summaries

All 34

Developmental Gene Expression 2

Diseases 1

Gene Ontology 1

Phenotypes 11
Earliest

J:54635 Liu H, et al., Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene. J Neurochem. 1999 May;72(5):1781-90
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Gdap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30873	Chr3:100069770-100069852 (+)	114 bp
Tssr30874	Chr3:100069870-100069881 (+)	179 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23