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Sdcbp Gene Detail
Summary
  • Symbol
    Sdcbp
  • Name
    syndecan binding protein
  • Synonyms
    MDA-9, Sycl, syndecan interacting protein, syntenin, syntenin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337026
    NCBI Gene: 53378
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:6365654-6396122 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 2.91 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337026
 protein coding gene Chr4:6365650-6408423 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028035
 protein coding gene Chr4:2869177-2913926 (+)
A/J MGP_AJ_G0027993
 protein coding gene Chr4:2893570-2936899 (+)
AKR/J MGP_AKRJ_G0027959
 protein coding gene Chr4:2884826-2927409 (+)
BALB/cJ MGP_BALBcJ_G0028005
 protein coding gene Chr4:2851775-2894320 (+)
C3H/HeJ MGP_C3HHeJ_G0027735
 protein coding gene Chr4:3020864-3064152 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028448
 protein coding gene Chr4:3108360-3152059 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025792
 protein coding gene Chr4:2633761-2676975 (+)
CAST/EiJ MGP_CASTEiJ_G0027188
 protein coding gene Chr4:2887631-2933858 (+)
CBA/J MGP_CBAJ_G0027710
 protein coding gene Chr4:3116160-3160843 (+)
DBA/2J MGP_DBA2J_G0027850
 protein coding gene Chr4:2866883-2910980 (+)
FVB/NJ MGP_FVBNJ_G0027817
 protein coding gene Chr4:2751654-2794111 (+)
LP/J MGP_LPJ_G0027961
 protein coding gene Chr4:2927330-2973443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027850
 protein coding gene Chr4:3335037-3379454 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028507
 protein coding gene Chr4:2877914-2920462 (+)
PWK/PhJ MGP_PWKPhJ_G0026910
 protein coding gene Chr4:2901918-2946878 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026740
 protein coding gene Chr4:2836630-2880464 (+)
WSB/EiJ MGP_WSBEiJ_G0027268
 protein coding gene Chr4:2978880-3023403 (+)



Homology
more
  • Human Ortholog
    SDCBP, syndecan binding protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDCBP, syndecan binding protein
  • Synonyms
    MDA9, MDA-9, SDCBP1, ST1, SYCL, TACIP18
  • Links
    NCBI Gene ID: 6386
    neXtProt AC: NX_O00560
    UniProt: O00560

  • Chr Location
    8q12.1; chr8:58552924-58582859 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    14 phenotype references
Mice heterozygous for a conditional allele activated in neurons exhibit abnormal dendrite morphology and reduced mEPSC frequency. Mice homozygous for a null allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    94
  • cDNA Data
    44
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 53378 NCBI Gene Model | MGI Sequence Detail 30469 C57BL/6J ±  kb
transcript NM_001424993 RefSeq | MGI Sequence Detail 2849 C57BL/6  
polypeptide O08992 UniProt | EBI | MGI Sequence Detail 299 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 45
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 60
    Developmental Gene Expression 5
    Gene Ontology 13
    Phenotypes 14
  • Earliest
    J:113829 Grootjans JJ, et al., Syntenin, a PDZ protein that binds syndecan cytoplasmic domains. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13683-8
  • Latest
    J:343223 Maji S, et al., MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis. Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2307094120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory