Slc22a18 MGI Mouse Gene Detail - MGI:1336884 - solute carrier family 22 (organic cation transporter), member 18

Symbol

Slc22a18
Name

solute carrier family 22 (organic cation transporter), member 18
Synonyms

BWR1A, BWSCR1A, Impt1, IMPT1, Orctl2, p45-BWR1A, Slc22a1l, TSSC5

Feature Type

protein coding gene
IDs

MGI:1336884
NCBI Gene: 18400
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr7:143027473-143053071 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 88.22 cM
Mapping Data

15 experiments

SNPs within 2kb

296 from dbSNP Build 142
Strain Annotations

18
PCR

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1336884	protein coding gene	Chr7:143027463-143053071 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033273	protein coding gene	Chr7:148758523-148798298 (+)
A/J	MGP_AJ_G0033256	protein coding gene	Chr7:144444143-144482035 (+)
AKR/J	MGP_AKRJ_G0033187	protein coding gene	Chr7:148494632-148532503 (+)
BALB/cJ	MGP_BALBcJ_G0033256	protein coding gene	Chr7:144229223-144267190 (+)
C3H/HeJ	MGP_C3HHeJ_G0032972	protein coding gene	Chr7:148258959-148296953 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033766	protein coding gene	Chr7:154129642-154169055 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030739	protein coding gene	Chr7:145668691-145701277 (+)
CAST/EiJ	MGP_CASTEiJ_G0032294	protein coding gene	Chr7:140586135-140614810 (+)
CBA/J	MGP_CBAJ_G0032943	protein coding gene	Chr7:159401145-159427336 (+)
DBA/2J	MGP_DBA2J_G0033097	protein coding gene	Chr7:142416490-142455633 (+)
FVB/NJ	MGP_FVBNJ_G0033045	protein coding gene	Chr7:142358200-142389198 (+)
LP/J	MGP_LPJ_G0033189	protein coding gene	Chr7:150282514-150320248 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033079	protein coding gene	Chr7:159981896-160021873 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033786	protein coding gene	Chr7:147465285-147509134 (+)
PWK/PhJ	MGP_PWKPhJ_G0032003	protein coding gene	Chr7:135729872-135768421 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031849	protein coding gene	Chr7:134275255-134314249 (+)
WSB/EiJ	MGP_WSBEiJ_G0032406	protein coding gene	Chr7:148478208-148504685 (+)

Human Ortholog

SLC22A18, solute carrier family 22 member 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A18, solute carrier family 22 member 18
Synonyms

BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, p45-BWR1A, SLC22A1L, TSSC5
Links

HGNC:10964

NCBI Gene ID: 5002

neXtProt AC: NX_Q96BI1

UniProt: Q96BI1
Chr Location

11p15.4; chr11:2899721-2925246 (+) GRCh38.p7

Alliance of Genome Resources

Slc22a18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC22A18
Gene Tree

Slc22a18

Diseases

2 with human SLC22A18 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				esophagus adenocarcinoma IDs esophagus adenocarcinoma DOID:4914 MESH:C562730 NCI:C4025 UMLS_CUI:C0279628

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

3 with disease annotations

References

3 with disease annotations

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Phenotype Summary

25 phenotypes from multigenic genotypes
11 phenotype references

All Mutations and Alleles

8
Endonuclease-mediated

1
Targeted

4
Transgenic

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

16
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

986
Tissues

165
cDNA Data

14
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Slc22a18 interacts with 132 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

70
RefSeq

18
UniProt

6
CCDS

CCDS22041.1

Ensembl

ENSMUSG00000000154 (Evidence)
NCBI Gene

18400

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000154	Ensembl Gene Model \| MGI Sequence Detail	25599	C57BL/6J	± kb
transcript	ENSMUST00000052348	Ensembl \| MGI Sequence Detail	1525	Not Applicable
polypeptide	ENSMUSP00000056082	Ensembl \| MGI Sequence Detail	410	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000014986 solute carrier family 22 member 18

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG

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All nucleic 36

Genomic 14

cDNA 14

Primer pair 8

Microarray probesets 5

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MGI:1202892, MGI:1332650, MGI:2142225

Summaries

All 60

Developmental Gene Expression 16

Diseases 3

Gene Ontology 5

Phenotypes 11
Earliest

J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
Latest

J:274138 Singh VB, et al., Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome. Development. 2017 May 15;144(10):1820-1830

TSS for Slc22a18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70291	Chr7:143027487-143027545 (+)	43 bp
Tssr70292	Chr7:143028831-143028852 (+)	1,369 bp
Tssr70293	Chr7:143028857-143028899 (+)	1,405 bp
Tssr70294	Chr7:143028903-143028929 (+)	1,443 bp
Tssr70295	Chr7:143028938-143028944 (+)	1,468 bp
Tssr70296	Chr7:143029847-143029859 (+)	2,380 bp
Tssr70297	Chr7:143029869-143029897 (+)	2,410 bp
Tssr70298	Chr7:143029900-143029929 (+)	2,442 bp
Tssr70299	Chr7:143029969-143029982 (+)	2,503 bp
Tssr70300	Chr7:143033446-143033494 (+)	5,997 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/24/2023 MGI 6.22