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Hpca Gene Detail
Summary
  • Symbol
    Hpca
  • Name
    hippocalcin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336200
    NCBI Gene: 15444
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129005363-129015829 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 62.88 cM, cytoband D2-D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336200
protein coding gene Chr4:129005363-129019712 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028813
protein coding gene Chr4:130968994-130979486 (-)
A/J MGP_AJ_G0028772
protein coding gene Chr4:125784466-125794883 (-)
AKR/J MGP_AKRJ_G0028725
protein coding gene Chr4:129274021-129284453 (-)
BALB/cJ MGP_BALBcJ_G0028795
protein coding gene Chr4:126363826-126374252 (-)
C3H/HeJ MGP_C3HHeJ_G0028509
protein coding gene Chr4:129321413-129331834 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029237
protein coding gene Chr4:135929259-135941806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026510
protein coding gene Chr4:118912032-118922772 (-)
CAST/EiJ MGP_CASTEiJ_G0027941
protein coding gene Chr4:127484313-127508909 (-)
CBA/J MGP_CBAJ_G0028475
protein coding gene Chr4:139245008-139258876 (-)
DBA/2J MGP_DBA2J_G0028624
protein coding gene Chr4:126211633-126222065 (-)
FVB/NJ MGP_FVBNJ_G0028591
protein coding gene Chr4:124967637-124978795 (-)
LP/J MGP_LPJ_G0028725
protein coding gene Chr4:131279114-131291775 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028617
protein coding gene Chr4:144153238-144164949 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029275
protein coding gene Chr4:129641246-129652819 (-)
PWK/PhJ MGP_PWKPhJ_G0027662
protein coding gene Chr4:122773627-122794847 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027490
protein coding gene Chr4:125495557-125506660 (-)
WSB/EiJ MGP_WSBEiJ_G0028022
protein coding gene Chr4:129747915-129760346 (-)



Homology
more
  • Human Ortholog
    HPCA, hippocalcin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPCA, hippocalcin
  • Synonyms
    BDR2, DYT2
  • Links
    NCBI Gene ID: 3208
    neXtProt AC: NX_P84074
    UniProt: P84074

  • Chr Location
    1p35.1; chr1:32885994-32898441 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human HPCA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit an age-dependent increase in neurodegeneration in the hippocampus and the cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028785 Ensembl Gene Model | MGI Sequence Detail 10467 C57BL/6J ±  kb
    transcript ENSMUST00000095807 Ensembl | MGI Sequence Detail 1666 Not Applicable  
    polypeptide ENSMUSP00000093486 Ensembl | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 25
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:51993 Masaki T, et al., Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes. Gene. 1998 Dec 28;225(1-2):117-24
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/21/2024
    MGI 6.23
    The Jackson Laboratory