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Pitpnm2 Gene Detail
Summary
  • Symbol
    Pitpnm2
  • Name
    phosphatidylinositol transfer protein, membrane-associated 2
  • Synonyms
    mKIAA1457, NIR3, Rdgb2, RDGBA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336192
    NCBI Gene: 19679
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124256753-124387823 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3169 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336192
 protein coding gene Chr5:124256753-124387973 (-)
129S1/SvImJ ENSMUSG00200027891
 protein coding gene Chr5:117979802-118110879 (-)
A/J ENSMUSG00195012139
 protein coding gene Chr5:117501343-117632435 (-)
AKR/J ENSMUSG00220039781
 protein coding gene Chr5:117011331-117142122 (-)
BALB/cJ ENSMUSG00180035875
 protein coding gene Chr5:117616256-117747360 (-)
C3H/HeJ ENSMUSG00175024416
 protein coding gene Chr5:119617573-119748356 (-)
C57BL/6NJ ENSMUSG00215038001
 protein coding gene Chr5:117665856-117796936 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027745
 protein coding gene Chr5:117121348-117252454 (-)
CAST/EiJ ENSTCUG00005039315
 protein coding gene Chr5:116901166-117032873 (-)
CBA/J ENSMUSG00210009750
 protein coding gene Chr5:118368541-118499317 (-)
DBA/2J ENSMUSG00185006623
 protein coding gene Chr5:121419598-121550378 (-)
FVB/NJ ENSMUSG00205040719
 protein coding gene Chr5:117293708-117424802 (-)
JF1/MsJ ENSUMUG00000034621
 protein coding gene Chr5:124277599-124408937 (-)
LP/J ENSMUSG00230045028
 protein coding gene Chr5:125501716-125632783 (-)
NOD/ShiLtJ ENSMUSG00190039137
 protein coding gene Chr5:117293979-117424750 (-)
NZO/HlLtJ ENSMUSG00225013258
 protein coding gene Chr5:133198679-133329726 (-)
PWK/PhJ ENSLUMG00010040766
 protein coding gene Chr5:116180744-116311869 (-)
SPRET/EiJ ENSMSPG00010043796
 protein coding gene Chr5:119482524-119580933 (-)
WSB/EiJ ENSIUOG00005014931
 protein coding gene Chr5:119993677-120124649 (-)



Homology
more
  • Human Ortholog
    PITPNM2, phosphatidylinositol transfer protein membrane associated 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PITPNM2, phosphatidylinositol transfer protein membrane associated 2
  • Synonyms
    NIR-3, NIR3, RDGB2, RDGBA2
  • Links
    NCBI Gene ID: 57605
    UniProt: Q9BZ72

  • Chr Location
    12q24.31; chr12:122983480-123151848 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
Homozygous null mice are viable, fertile, and show no defects pertaining to photoreceptor function or survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    677
  • Tissues
    57
  • cDNA Data
    49
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029406 Ensembl Gene Model | MGI Sequence Detail 131071 C57BL/6J ±  kb
transcript ENSMUST00000161938 Ensembl | MGI Sequence Detail 5866 Not Applicable  
polypeptide ENSMUSP00000124111 Ensembl | MGI Sequence Detail 1335 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    cDNA 51
    Primer pair 2
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 48
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:340925 Lu W, et al., The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P(2) replenishment in response to TCR signaling during T cell development and survival. Nat Immunol. 2023 Jan;24(1):136-147
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory