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Prkab1 Gene Detail
Summary
  • Symbol
    Prkab1
  • Name
    protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • Synonyms
    1300015D22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336167
    NCBI Gene: 19079
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:116151645-116162567 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.10 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336167
 protein coding gene Chr5:116151645-116162596 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029978
 protein coding gene Chr5:118948579-118959353 (-)
A/J MGP_AJ_G0029942
 protein coding gene Chr5:114195107-114206040 (-)
AKR/J MGP_AKRJ_G0029881
 protein coding gene Chr5:117861025-117871807 (-)
BALB/cJ MGP_BALBcJ_G0029953
 protein coding gene Chr5:115597345-115608127 (-)
C3H/HeJ MGP_C3HHeJ_G0029673
 protein coding gene Chr5:118378466-118389388 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030408
 protein coding gene Chr5:123518058-123528981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027634
 protein coding gene Chr5:108967764-108978892 (-)
CAST/EiJ MGP_CASTEiJ_G0029082
 protein coding gene Chr5:117337253-117349860 (-)
CBA/J MGP_CBAJ_G0029641
 protein coding gene Chr5:128254162-128265084 (-)
DBA/2J MGP_DBA2J_G0029791
 protein coding gene Chr5:114287245-114298027 (-)
FVB/NJ MGP_FVBNJ_G0029747
 protein coding gene Chr5:113113445-113124354 (-)
LP/J MGP_LPJ_G0029879
 protein coding gene Chr5:119505746-119516556 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029778
 protein coding gene Chr5:132550759-132561826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030449
 protein coding gene Chr5:117343188-117353969 (-)
PWK/PhJ MGP_PWKPhJ_G0028795
 protein coding gene Chr5:112941923-112953423 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028633
 protein coding gene Chr5:114891235-114903233 (-)
WSB/EiJ MGP_WSBEiJ_G0029157
 protein coding gene Chr5:117940711-117951479 (-)



Homology
more
  • Human Ortholog
    PRKAB1, protein kinase AMP-activated non-catalytic subunit beta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAB1, protein kinase AMP-activated non-catalytic subunit beta 1
  • Synonyms
    AMPK, HAMPKb
  • Links
    NCBI Gene ID: 5564
    neXtProt AC: NX_Q9Y478
    UniProt: Q9Y478

  • Chr Location
    12q24.23; chr12:119667864-119681624 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    123 phenotypes from 7 alleles in 17 genetic backgrounds
    8 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele exhibit altered brain development, seizures, and postnatal death. Homozygotes for a null allele are protected from diet-induced obesity and hepatic insulin resistance. Homozygotes for another null allele show microcytic anemia and extramedullary hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1796
  • Tissues
    100
  • cDNA Data
    118
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029513 Ensembl Gene Model | MGI Sequence Detail 10923 C57BL/6J ±  kb
    transcript ENSMUST00000031486 Ensembl | MGI Sequence Detail 2089 Not Applicable  
    polypeptide ENSMUSP00000031486 Ensembl | MGI Sequence Detail 270 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 120
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923533, MGI:2141055
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 51
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:331949 Johanns M, et al., Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators. Biochem J. 2022 Jun 30;479(12):1317-1336
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    03/14/2023
    MGI 6.22     		The Jackson Laboratory