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Prkab1 Gene Detail
Summary
  • Symbol
    Prkab1
  • Name
    protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • Synonyms
    1300015D22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336167
    NCBI Gene: 19079
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:116151654-116162449 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.10 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    440 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336167
 protein coding gene Chr5:116151645-116162567 (-)
129S1/SvImJ ENSMUSG00200020876
 protein coding gene Chr5:109892596-109903378 (-)
A/J ENSMUSG00195031322
 protein coding gene Chr5:109412729-109423664 (-)
AKR/J ENSMUSG00220050926
 protein coding gene Chr5:108922346-108933128 (-)
BALB/cJ ENSMUSG00180044693
 protein coding gene Chr5:109543373-109554156 (-)
C3H/HeJ ENSMUSG00175045855
 protein coding gene Chr5:111530523-111541445 (-)
C57BL/6NJ ENSMUSG00215031326
 protein coding gene Chr5:109553094-109564016 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027634
 protein coding gene Chr5:108967764-108978892 (-)
CAST/EiJ ENSTCUG00005030964
 protein coding gene Chr5:108734264-108745233 (-)
CBA/J ENSMUSG00210032957
 protein coding gene Chr5:110281562-110292484 (-)
DBA/2J ENSMUSG00185051207
 protein coding gene Chr5:113341612-113352394 (-)
FVB/NJ ENSMUSG00205026384
 protein coding gene Chr5:109181895-109192818 (-)
JF1/MsJ ENSUMUG00000034707
 protein coding gene Chr5:116165119-116176171 (-)
LP/J ENSMUSG00230046947
 protein coding gene Chr5:117430731-117441513 (-)
NOD/ShiLtJ ENSMUSG00190045234
 protein coding gene Chr5:109217275-109228208 (-)
NZO/HlLtJ ENSMUSG00225015755
 protein coding gene Chr5:125091020-125101802 (-)
PWK/PhJ ENSLUMG00010024844
 protein coding gene Chr5:108058434-108069489 (-)
SPRET/EiJ ENSMSPG00010036230
 protein coding gene Chr5:111350508-111361420 (-)
WSB/EiJ ENSIUOG00005039950
 protein coding gene Chr5:111923274-111934049 (-)



Homology
more
  • Human Ortholog
    PRKAB1, protein kinase AMP-activated non-catalytic subunit beta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAB1, protein kinase AMP-activated non-catalytic subunit beta 1
  • Synonyms
    AMPK, HAMPKb
  • Links
    NCBI Gene ID: 5564
    UniProt: Q9Y478

  • Chr Location
    12q24.23; chr12:119667864-119681624 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    120 phenotypes from 6 alleles in 16 genetic backgrounds
    8 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene trap allele exhibit altered brain development, seizures, and postnatal death. Homozygotes for a null allele are protected from diet-induced obesity and hepatic insulin resistance. Homozygotes for another null allele show microcytic anemia and extramedullary hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1687
  • Tissues
    100
  • cDNA Data
    118
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19079 NCBI Gene Model | MGI Sequence Detail 10796 C57BL/6J ±  kb
    transcript NM_031869 RefSeq | MGI Sequence Detail 2008 C57BL/6  
    polypeptide Q9R078 UniProt | EBI | MGI Sequence Detail 270 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013220 5'-AMP-activated protein kinase subunit beta-1
      (term hierarchy)
    • InterPro Domains
      IPR032640 AMP-activated protein kinase, glycogen-binding domain
      IPR037256 ASC domain superfamily
      IPR006828 Association with the SNF1 complex (ASC) domain
      IPR050827 CRP1/MDG1 DNA-binding & kinase subunit
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
    • GlyGen
      Q9R078 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 120
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923533, MGI:2141055
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 7
      Gene Ontology 11
      Phenotypes 62
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory