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Fem1a Gene Detail
Summary
  • Symbol
    Fem1a
  • Name
    fem 1 homolog a
  • Synonyms
    Eprap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1335089
    NCBI Gene: 14154
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56563810-56570610 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    13
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1335089
 protein coding gene Chr17:56563793-56570610 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023919
 protein coding gene Chr17:57923771-57930693 (+)
A/J MGP_AJ_G0023878
 protein coding gene Chr17:56353122-56361025 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0018053
 protein coding gene Chr11:27021290-27028134 (-)
C3H/HeJ MGP_C3HHeJ_G0023643
 protein coding gene Chr17:57747975-57757531 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024324
 protein coding gene Chr17:60198956-60206374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021771
 protein coding gene Chr17:52842960-52849762 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0017943
 protein coding gene Chr11:26482301-26485229 (-)
LP/J MGP_LPJ_G0023828
 protein coding gene Chr17:58616446-58625429 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023741
 protein coding gene Chr17:62046051-62053548 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024369
 protein coding gene Chr17:57408624-57414904 (+)
PWK/PhJ MGP_PWKPhJ_G0022871
 protein coding gene Chr17:54414635-54421941 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0023190
 protein coding gene Chr17:58014211-58020734 (+)



Homology
more
  • Human Ortholog
    FEM1A, fem-1 homolog A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FEM1A, fem-1 homolog A
  • Synonyms
    EPRAP
  • Links
    NCBI Gene ID: 55527
    neXtProt AC: NX_Q9BSK4
    UniProt: Q9BSK4

  • Chr Location
    19p13.3; chr19:4791734-4801273 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in an increased susceptibility to DSS-induced colitis and colitis-associated tumorigenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    43
  • cDNA Data
    113
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043683 Ensembl Gene Model | MGI Sequence Detail 6801 C57BL/6J ±  kb
    transcript ENSMUST00000060253 Ensembl | MGI Sequence Detail 6801 Not Applicable  
    polypeptide ENSMUSP00000057996 Ensembl | MGI Sequence Detail 654 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 113

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147095
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:51387 Ventura-Holman T, et al., The murine fem1 gene family: homologs of the Caenorhabditis elegans sex- determination protein FEM-1. Genomics. 1998 Dec 1;54(2):221-30
    • Latest
      J:273894 Higuchi S, et al., EP4 receptor-associated protein regulates gluconeogenesis in the liver and is associated with hyperglycemia in diabetic mice. Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E410-E417
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory