Neurl1a MGI Mouse Gene Detail - MGI:1334263 - neuralized E3 ubiquitin protein ligase 1A

Symbol

Neurl1a
Name

neuralized E3 ubiquitin protein ligase 1A
Synonyms

2410129E16Rik, Neu1, Neur1, Neurl, Nlz, Rnf67

Feature Type

protein coding gene
IDs

MGI:1334263
NCBI Gene: 18011
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr19:47167259-47247880 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 39.39 cM
Mapping Data

3 experiments

SNPs within 2kb

862 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1334263	protein coding gene	Chr19:47167259-47247880 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025228	protein coding gene	Chr19:46966288-47056259 (+)
A/J	MGP_AJ_G0025204	protein coding gene	Chr19:44615162-44699752 (+)
AKR/J	MGP_AKRJ_G0025173	protein coding gene	Chr19:46080449-46159993 (+)
BALB/cJ	MGP_BALBcJ_G0025199	protein coding gene	Chr19:44675556-44759169 (+)
C3H/HeJ	MGP_C3HHeJ_G0024959	protein coding gene	Chr19:46263858-46347873 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025642	protein coding gene	Chr19:48098693-48192062 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023055	protein coding gene	Chr19:43860148-43938834 (+)
CAST/EiJ	MGP_CASTEiJ_G0024424	protein coding gene	Chr19:46070935-46152417 (+)
CBA/J	MGP_CBAJ_G0024939	protein coding gene	Chr19:50528612-50626093 (+)
DBA/2J	MGP_DBA2J_G0025071	protein coding gene	Chr19:44429432-44509903 (+)
FVB/NJ	MGP_FVBNJ_G0025032	protein coding gene	Chr19:44230837-44309159 (+)
LP/J	MGP_LPJ_G0025157	protein coding gene	Chr19:46862533-46945844 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025063	protein coding gene	Chr19:49816429-49901646 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025700	protein coding gene	Chr19:46201152-46283188 (+)
PWK/PhJ	MGP_PWKPhJ_G0024173	protein coding gene	Chr19:44398312-44480176 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023976	protein coding gene	Chr19:44850105-44936604 (+)
WSB/EiJ	MGP_WSBEiJ_G0024494	protein coding gene	Chr19:46354978-46441222 (+)

Human Ortholog

NEURL1, neuralized E3 ubiquitin protein ligase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEURL1, neuralized E3 ubiquitin protein ligase 1
Synonyms

bA416N2.1, neu, neu-1, NEUR1, NEURL, RNF67
Links

HGNC:7761

NCBI Gene ID: 9148

neXtProt AC: NX_O76050

UniProt: O76050
Chr Location

10q24.33; chr10:103493705-103592546 (+) GRCh38

MGI Vertebrate Homology

Neurl1a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NEURL1
Gene Tree

Neurl1a

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Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

1
Gene trapped

12
Targeted

6
Transgenic

2
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Depending on the targeted mutation, homozygotes show a spectrum of conflicting phenotypes ranging from axonemal and spermatid abnormalities, male sterility and deficient lactation, to just a specific olfactory discrimination defect and ethanol hypersensitivity on motor coordination.

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All GO Annotations

41
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

30
cDNA Data

33
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase neurl1

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All Sequences

51
RefSeq

6
UniProt

3
CCDS

CCDS29890.1, CCDS50463.1

Ensembl

ENSMUSG00000006435 (Evidence)
NCBI Gene

18011

			Length	Strain/Species	Flank
genomic	18011	NCBI Gene Model \| MGI Sequence Detail	80622	C57BL/6J	± kb
transcript	NM_021360	RefSeq \| MGI Sequence Detail	4168	ZRU/MplStud
polypeptide	Q923S6	UniProt \| EBI \| MGI Sequence Detail	574	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011149 E3 ubiquitin-protein ligase NEURL1

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR043136 B30.2/SPRY domain superfamily

IPR037962 Neuralized

IPR006573 Neuralized homology repeat (NHR) domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 38

cDNA 34

Primer pair 2

Other 2

Microarray probesets 9

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MGI:1920954, MGI:2147547, MGI:2147565

Summaries

All 47

Developmental Gene Expression 9

Gene Ontology 13

Phenotypes 8
Earliest

J:51115 Hansen GM, et al., A mouse chromosome 19 genetic map including the Lvis1 viral insertion site. Genomics. 1999 Mar 1;56(2):228-31
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Neurl1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156848	Chr19:47167386-47167436 (+)	152 bp
Tssr156849	Chr19:47167443-47167469 (+)	197 bp
Tssr156850	Chr19:47167477-47167518 (+)	239 bp
Tssr156851	Chr19:47167555-47167615 (+)	326 bp
Tssr156852	Chr19:47167798-47167814 (+)	547 bp
Tssr156853	Chr19:47167820-47167851 (+)	577 bp
Tssr156854	Chr19:47217243-47217254 (+)	49,990 bp
Tssr5543	Chr19:47217279-47217311 (+)	50,036 bp
Tssr156855	Chr19:47217459-47217486 (+)	50,214 bp
Tssr156856	Chr19:47217505-47217512 (+)	50,250 bp
Tssr156857	Chr19:47228763-47228788 (+)	61,517 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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