Klf9 MGI Mouse Gene Detail - MGI:1333856 - Kruppel-like transcription factor 9

Symbol

Klf9
Name

Kruppel-like transcription factor 9
Synonyms

2310051E17Rik, Bteb1, BTEB-1, Klf9

Feature Type

protein coding gene
IDs

MGI:1333856
NCBI Gene: 16601
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr19:23118590-23145493 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 17.90 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333856	protein coding gene	Chr19:23118590-23145498 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024983	protein coding gene	Chr19:21269406-21299439 (+)
A/J	MGP_AJ_G0024960	protein coding gene	Chr19:20106309-20131817 (+)
AKR/J	MGP_AKRJ_G0024930	protein coding gene	Chr19:20879568-20905372 (+)
BALB/cJ	MGP_BALBcJ_G0024959	protein coding gene	Chr19:20148590-20174541 (+)
C3H/HeJ	MGP_C3HHeJ_G0024717	protein coding gene	Chr19:20841101-20866305 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025401	protein coding gene	Chr19:21959912-21988627 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022820	protein coding gene	Chr19:20292188-20319033 (+)
CAST/EiJ	MGP_CASTEiJ_G0024185	protein coding gene	Chr19:20548420-20575549 (+)
CBA/J	MGP_CBAJ_G0024695	protein coding gene	Chr19:22889864-22918835 (+)
DBA/2J	MGP_DBA2J_G0024827	protein coding gene	Chr19:20124173-20149746 (+)
FVB/NJ	MGP_FVBNJ_G0024788	protein coding gene	Chr19:19973805-20001094 (+)
LP/J	MGP_LPJ_G0024911	protein coding gene	Chr19:21221463-21248119 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024815	protein coding gene	Chr19:22976121-23017452 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025456	protein coding gene	Chr19:20862861-20890005 (+)
PWK/PhJ	MGP_PWKPhJ_G0023934	protein coding gene	Chr19:19693886-19719540 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023739	protein coding gene	Chr19:20085525-20109613 (+)
WSB/EiJ	MGP_WSBEiJ_G0024253	protein coding gene	Chr19:20887574-20915739 (+)

Human Ortholog

KLF9, KLF transcription factor 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLF9, KLF transcription factor 9
Synonyms

BTEB, BTEB1
Links

HGNC:1123

NCBI Gene ID: 687

neXtProt AC: NX_Q13886

UniProt: Q13886
Chr Location

9q21.12; chr9:70384604-70414657 (-) GRCh38

MGI Vertebrate Homology

Klf9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLF9
Gene Tree

Klf9

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

314
Endonuclease-mediated

3
Gene trapped

304
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

122 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice display only mild neurological defects evident by impaired performance in rotarod and contextual fear-conditioning tests.

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All GO Annotations

21
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1081
Tissues

154
cDNA Data

17
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klf9

ZFIN klf9

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All Sequences

45
RefSeq

2
UniProt

2
CCDS

CCDS29706.1

Ensembl

ENSMUSG00000033863 (Evidence)
NCBI Gene

16601

			Length	Strain/Species	Flank
genomic	16601	NCBI Gene Model \| MGI Sequence Detail	26904	C57BL/6J	± kb
transcript	NM_010638	RefSeq \| MGI Sequence Detail	4481	C57BL/6
polypeptide	O35739	UniProt \| EBI \| MGI Sequence Detail	244	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009369 krueppel-like factor 9

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 22

cDNA 18

Primer pair 4

Microarray probesets 10

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MGI:1917523, MGI:2147456

Summaries

All 99

Developmental Gene Expression 19

Gene Ontology 7

Phenotypes 44
Earliest

J:51610 Imhof A, et al., Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/ egr-related zinc finger repressor. Mol Cell Biol. 1999 Jan;19(1):194-204
Latest

J:334235 Bernhardt C, et al., KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF. Nucleic Acids Res. 2022 Nov 11;50(20):11509-11528

TSS for Klf9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155578	Chr19:23117471-23117475 (+)	-1,117 bp
Tssr155579	Chr19:23118186-23118205 (+)	-394 bp
Tssr155580	Chr19:23118304-23118315 (+)	-280 bp
Tssr155581	Chr19:23118320-23118331 (+)	-264 bp
Tssr155582	Chr19:23118343-23118368 (+)	-234 bp
Tssr155583	Chr19:23118383-23118397 (+)	-200 bp
Tssr155584	Chr19:23118428-23118441 (+)	-155 bp
Tssr155585	Chr19:23118490-23118501 (+)	-94 bp
Tssr155586	Chr19:23118547-23118627 (+)	-3 bp
Tssr155587	Chr19:23119006-23119031 (+)	429 bp
Tssr155588	Chr19:23119040-23119065 (+)	463 bp
Tssr155589	Chr19:23142591-23142604 (+)	24,008 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23