Slc22a3 MGI Mouse Gene Detail - MGI:1333817 - solute carrier family 22 (organic cation transporter), member 3

Symbol

Slc22a3
Name

solute carrier family 22 (organic cation transporter), member 3
Synonyms

EMT, Oct3, Orct3

Feature Type

protein coding gene
IDs

MGI:1333817
NCBI Gene: 20519
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:12638859-12726591 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.52 cM
Mapping Data

4 experiments

SNPs within 2kb

2180 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333817	protein coding gene	Chr17:12637847-12726591 (-)
129S1/SvImJ	ENSMUSG00200031387	protein coding gene	Chr17:8863638-8952180 (-)
A/J	ENSMUSG00195021546	protein coding gene	Chr17:9062508-9151250 (-)
AKR/J	ENSMUSG00220027392	protein coding gene	Chr17:9129092-9217644 (-)
BALB/cJ	ENSMUSG00180022033	protein coding gene	Chr17:8713053-8800694 (-)
C3H/HeJ	ENSMUSG00175030241	protein coding gene	Chr17:8855875-8944610 (-)
C57BL/6NJ	ENSMUSG00215022826	protein coding gene	Chr17:8907124-8995865 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021051	protein coding gene	Chr17:4446163-4534055 (+)
CAST/EiJ	ENSTCUG00005021294	protein coding gene	Chr17:9103638-9194714 (-)
CBA/J	ENSMUSG00210036179	protein coding gene	Chr17:8519124-8607863 (-)
DBA/2J	ENSMUSG00185022035	protein coding gene	Chr17:9612090-9700824 (-)
FVB/NJ	ENSMUSG00205008808	protein coding gene	Chr17:8946402-9035148 (-)
JF1/MsJ	ENSUMUG00000031364	protein coding gene	Chr17:9194317-9286598 (-)
LP/J	ENSMUSG00230020597	protein coding gene	Chr17:11047295-11135848 (-)
NOD/ShiLtJ	ENSMUSG00190029181	protein coding gene	Chr17:9048039-9136788 (-)
NZO/HlLtJ	ENSMUSG00225047442	protein coding gene	Chr17:12966165-13054713 (-)
PWK/PhJ	ENSLUMG00010017921	protein coding gene	Chr17:9036713-9128857 (-)
SPRET/EiJ	ENSMSPG00010032591	protein coding gene	Chr17:4518034-4606081 (+)
WSB/EiJ	ENSIUOG00005013135	protein coding gene	Chr17:8944322-9033104 (-)

Human Ortholog

SLC22A3, solute carrier family 22 member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC22A3, solute carrier family 22 member 3
Synonyms

EMT, EMTH, hOCT3, OCT3
Links

HGNC:10967

NCBI Gene ID: 6581

UniProt: O75751
Chr Location

6q25.3; chr6:160348373-160452577 (+) GRCh38

MGI Vertebrate Homology

Slc22a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC22A3
Gene Tree

Slc22a3

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Phenotype Summary

15 phenotypes from 2 alleles in 3 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased susceptibility to paraquat-induced dopamine neuron neurotoxicity.

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All GO Annotations

117
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

33
cDNA Data

11
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS28391.1

Ensembl

ENSMUSG00000023828 (Evidence)
NCBI Gene

20519

			Length	Strain/Species	Flank
genomic	20519	NCBI Gene Model \| MGI Sequence Detail	87733	C57BL/6J	± kb
transcript	NM_011395	RefSeq \| MGI Sequence Detail	3501	C57BL/6
polypeptide	Q9WTW5	UniProt \| EBI \| MGI Sequence Detail	551	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014990 solute carrier family 22 member 3

(term hierarchy)
InterPro Domains

IPR005828 Major facilitator, sugar transporter-like

IPR020846 Major facilitator superfamily domain

IPR036259 MFS transporter superfamily

IPR004749 Organic cation transport protein/SVOP

IPR005829 Sugar transporter, conserved site
GlyGen

Q9WTW5 5 sites

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All nucleic 26

Genomic 6

cDNA 12

Primer pair 7

Other 1

Microarray probesets 3

Summaries

All 87

Developmental Gene Expression 14

Gene Ontology 21

Phenotypes 27
Earliest

J:52875 Verhaagh S, et al., Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics. 1999 Jan 15;55(2):209-18
Latest

J:389115 Honan LE, et al., It's not all DAT: harnessing the potential of organic cation transporter 3 inhibition to selectively attenuate amphetamine reinforcement and dopamine release. Neuropsychopharmacology. 2026 Mar 26;

TSS for Slc22a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146429	Chr17:12726609-12726614 (-)	-21 bp
Tssr146428	Chr17:12726283-12726295 (-)	302 bp
Tssr146427	Chr17:12726248-12726266 (-)	334 bp
Tssr146426	Chr17:12726242-12726247 (-)	346 bp
Tssr146425	Chr17:12726059-12726074 (-)	524 bp
Tssr146424	Chr17:12725983-12725994 (-)	602 bp
Tssr146423	Chr17:12639338-12639343 (-)	87,250 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24