About   Help   FAQ
Srsf10 Gene Detail
Summary
  • Symbol
    Srsf10
  • Name
    serine and arginine-rich splicing factor 10
  • Synonyms
    Fusip1, FUSIP2, Nssr, NSSR1, NSSR2, Sfrs13a, SRrp40, Srsf13a, TASR1, TASR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333805
    NCBI Gene: 14105
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135583058-135597219 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 68.01 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333805
protein coding gene Chr4:135582454-135597219 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028950
protein coding gene Chr4:138340842-138357268 (+)
A/J MGP_AJ_G0028909
protein coding gene Chr4:132471858-132486847 (+)
AKR/J MGP_AKRJ_G0028861
protein coding gene Chr4:136294186-136305380 (+)
BALB/cJ MGP_BALBcJ_G0028933
protein coding gene Chr4:133141028-133151566 (+)
C3H/HeJ MGP_C3HHeJ_G0028647
protein coding gene Chr4:136574644-136589463 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029374
protein coding gene Chr4:143250536-143263874 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026645
protein coding gene Chr4:125525028-125539401 (+)
CAST/EiJ MGP_CASTEiJ_G0028079
protein coding gene Chr4:134701779-134721324 (+)
CBA/J MGP_CBAJ_G0028612
protein coding gene Chr4:147184257-147194504 (+)
DBA/2J MGP_DBA2J_G0028761
protein coding gene Chr4:132888774-132916080 (+)
FVB/NJ MGP_FVBNJ_G0028728
protein coding gene Chr4:131817635-131834866 (+)
LP/J MGP_LPJ_G0028860
protein coding gene Chr4:138440752-138455753 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028754
protein coding gene Chr4:151469675-151483900 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029412
protein coding gene Chr4:136756466-136766875 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0027625
protein coding gene Chr4:132566322-132581341 (+)
WSB/EiJ MGP_WSBEiJ_G0028157
protein coding gene Chr4:136919610-136939025 (+)



Homology
more
  • Human Ortholog
    SRSF10, serine and arginine rich splicing factor 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRSF10, serine and arginine rich splicing factor 10
  • Synonyms
    FUSIP1, FUSIP2, NSSR, PPP1R149, SFRS13, SFRS13A, SRp38, SRrp40, TASR, TASR1, TASR2
  • Links
    NCBI Gene ID: 10772
    neXtProt AC: NX_O75494
    UniProt: O75494

  • Chr Location
    1p36.11; chr1:23964347-23980927 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit fetal and neonatal lethality associated with edema and cardiac defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028676 Ensembl Gene Model | MGI Sequence Detail 14162 C57BL/6J ±  kb
    transcript ENSMUST00000105853 Ensembl | MGI Sequence Detail 3058 Not Applicable  
    polypeptide ENSMUSP00000101479 Ensembl | MGI Sequence Detail 262 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 27
      Primer pair 4

      Microarray probesets 8
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:51309 Yang L, et al., Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem. 1998 Oct 23;273(43):27761-4
    • Latest
      J:337597 Li J, et al., SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex. iScience. 2023 Jul 21;26(7):107042

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory