Srp72 MGI Mouse Gene Detail - MGI:1333795 - signal recognition particle 72

Symbol

Srp72
Name

signal recognition particle 72
Synonyms

5730576P14Rik, 72kDa

Feature Type

protein coding gene
IDs

MGI:1333795
NCBI Gene: 66661
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:77122548-77147782 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 41.45 cM
Mapping Data

2 experiments

SNPs within 2kb

706 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333795	protein coding gene	Chr5:77122530-77147784 (+)
129S1/SvImJ	ENSMUSG00200000697	protein coding gene	Chr5:72812915-72838169 (+)
A/J	ENSMUSG00195010242	protein coding gene	Chr5:72119531-72144766 (+)
AKR/J	ENSMUSG00220014846	protein coding gene	Chr5:72231311-72256558 (+)
BALB/cJ	ENSMUSG00180000043	protein coding gene	Chr5:71884715-71909974 (+)
C3H/HeJ	ENSMUSG00175004145	protein coding gene	Chr5:73920602-73945854 (+)
C57BL/6NJ	ENSMUSG00215000433	protein coding gene	Chr5:72699279-72724532 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027323	protein coding gene	Chr5:69868102-69893347 (+)
CAST/EiJ	ENSTCUG00005013219	protein coding gene	Chr5:71672289-71697752 (+)
CBA/J	ENSMUSG00210000429	protein coding gene	Chr5:72858549-72883798 (+)
DBA/2J	ENSMUSG00185015784	protein coding gene	Chr5:74688492-74713739 (+)
FVB/NJ	ENSMUSG00205021219	protein coding gene	Chr5:71646810-71672074 (+)
JF1/MsJ	ENSUMUG00000005942	protein coding gene	Chr5:79180076-79205494 (+)
LP/J	ENSMUSG00230019997	protein coding gene	Chr5:79386870-79412125 (+)
NOD/ShiLtJ	ENSMUSG00190007637	protein coding gene	Chr5:71809906-71835137 (+)
NZO/HlLtJ	ENSMUSG00225033920	protein coding gene	Chr5:84433862-84459118 (+)
PWK/PhJ	ENSLUMG00010007496	protein coding gene	Chr5:71753528-71778704 (+)
SPRET/EiJ	ENSMSPG00010009685	protein coding gene	Chr5:73750672-73775191 (+)
WSB/EiJ	ENSIUOG00005017928	protein coding gene	Chr5:74655540-74680786 (+)

Human Ortholog

SRP72, signal recognition particle 72

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRP72, signal recognition particle 72
Synonyms

BMFF, BMFS1, HEL103
Links

HGNC:11303

NCBI Gene ID: 6731

UniProt: O76094
Chr Location

4q12; chr4:56467595-56503681 (+) GRCh38

MGI Vertebrate Homology

Srp72 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRP72
Protein SuperFamily

SRP72
Gene Tree

Srp72

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

4
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Srp72
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

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All GO Annotations

30
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

14

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srp72

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All Sequences

61
RefSeq

2
UniProt

7
CCDS

CCDS39119.1

Ensembl

ENSMUSG00000036323 (Evidence)
NCBI Gene

66661

			Length	Strain/Species	Flank
genomic	66661	NCBI Gene Model \| MGI Sequence Detail	25235	C57BL/6J	± kb
transcript	NM_025691	RefSeq \| MGI Sequence Detail	3605	C57BL/6
polypeptide	NP_079967	RefSeq \| MGI Sequence Detail	671	C57BL/6

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UniProt

7 Sequences
InterPro Domains

IPR026270 Signal recognition particle, SRP72 subunit

IPR013699 Signal recognition particle, SRP72 subunit, RNA-binding

IPR031545 Signal recognition particle subunit SRP72, TPR-like repeat

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat
GlyGen

F8VQC1 1 site, 1 N-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 6

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MGI:1913911, MGI:2140810, MGI:2141290, MGI:3039569

Summaries

All 50

Gene Ontology 9

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Srp72:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46757	Chr5:77122539-77122574 (+)	9 bp
Tssr46758	Chr5:77143617-77143636 (+)	21,079 bp
Tssr46759	Chr5:77143675-77143689 (+)	21,134 bp
Tssr46760	Chr5:77143696-77143707 (+)	21,154 bp
Tssr46761	Chr5:77143718-77143731 (+)	21,177 bp
Tssr46762	Chr5:77146048-77146082 (+)	23,517 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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