Artn MGI Mouse Gene Detail - MGI:1333791

Symbol

Artn
Name

artemin
Synonyms

neublastin

Feature Type

protein coding gene
IDs

MGI:1333791
NCBI Gene: 11876
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:117783359-117786960 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.83 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

157 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333791	protein coding gene	Chr4:117783105-117787993 (-)
129S1/SvImJ	ENSMUSG00200045921	protein coding gene	Chr4:111682201-111685802 (-)
A/J	ENSMUSG00195032376	protein coding gene	Chr4:112934655-112938257 (-)
AKR/J	ENSMUSG00220021211	protein coding gene	Chr4:112283733-112287333 (-)
BALB/cJ	ENSMUSG00180041136	protein coding gene	Chr4:111001863-111005463 (-)
C3H/HeJ	ENSMUSG00175036532	protein coding gene	Chr4:112016089-112019689 (-)
C57BL/6NJ	ENSMUSG00215036268	protein coding gene	Chr4:113108214-113111815 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026368	protein coding gene	Chr4:108371975-108375598 (-)
CAST/EiJ	ENSTCUG00005020529	protein coding gene	Chr4:111794898-111798512 (-)
CBA/J	ENSMUSG00210052666	protein coding gene	Chr4:111629765-111633365 (-)
DBA/2J	ENSMUSG00185039450	protein coding gene	Chr4:113160211-113163812 (-)
FVB/NJ	ENSMUSG00205018798	protein coding gene	Chr4:111099241-111102841 (-)
JF1/MsJ	ENSUMUG00000016967	protein coding gene	Chr4:113078542-113082155 (-)
LP/J	ENSMUSG00230041765	protein coding gene	Chr4:116497774-116501375 (-)
NOD/ShiLtJ	ENSMUSG00190042255	protein coding gene	Chr4:110997844-111001444 (-)
NZO/HlLtJ	ENSMUSG00225010463	protein coding gene	Chr4:121980478-121984079 (-)
PWK/PhJ	ENSLUMG00010046131	protein coding gene	Chr4:110461973-110465587 (-)
SPRET/EiJ	ENSMSPG00010030876	protein coding gene	Chr4:112560133-112562108 (-)
WSB/EiJ	ENSIUOG00005039918	protein coding gene	Chr4:111315689-111319289 (-)

Human Ortholog

ARTN, artemin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARTN, artemin
Synonyms

ART, ENOVIN, EVN, NBN
Links

HGNC:727

NCBI Gene ID: 9048

UniProt: Q5T4W7
Chr Location

1p34.1; chr1:43933320-43937244 (+) GRCh38

MGI Vertebrate Homology

Artn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ARTN
Gene Tree

Artn

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Phenotype Summary

12 phenotypes from 3 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Targeted

4
Transgenic

3
Genomic Mutations

4 involving Artn
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene display ptosis and poor development of the sympathetic chain ganglia and associated nerves.

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All GO Annotations

28
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

669
Tissues

47
cDNA Data

6
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase artn

ZFIN artnb

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All Sequences

58
RefSeq

22
UniProt

1
CCDS

CCDS18543.1

Ensembl

ENSMUSG00000028539 (Evidence)
NCBI Gene

11876

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028539	Ensembl Gene Model \| MGI Sequence Detail	3602	C57BL/6J	± kb
transcript	ENSMUST00000070816	Ensembl \| MGI Sequence Detail	2177	Not Applicable
polypeptide	ENSMUSP00000064521	Ensembl \| MGI Sequence Detail	224	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004331 artemin

(term hierarchy)
InterPro Domains

IPR029034 Cystine-knot cytokine

IPR043401 Glial cell line-derived neurotrophic factor family

IPR001839 Transforming growth factor-beta, C-terminal
GlyGen

Q9Z0L2 1 site

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All nucleic 14

Genomic 3

cDNA 7

Primer pair 2

Other 2

Antibodies 1

Microarray probesets 3

Summaries

All 74

Developmental Gene Expression 11

Gene Ontology 12

Phenotypes 18
Earliest

J:51795 Baloh RH, et al., Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron. 1998 Dec;21(6):1291-302
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Artn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43021	Chr4:117786946-117786973 (-)	0 bp
Tssr43020	Chr4:117786923-117786936 (-)	30 bp
Tssr43019	Chr4:117786690-117786707 (-)	261 bp
Tssr43018	Chr4:117786663-117786672 (-)	292 bp
Tssr43017	Chr4:117783958-117783967 (-)	2,997 bp
Tssr43016	Chr4:117783950-117783957 (-)	3,006 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29