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Artn Gene Detail
Summary
  • Symbol
    Artn
  • Name
    artemin
  • Synonyms
    neublastin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333791
    NCBI Gene: 11876
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117783359-117786960 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 53.83 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333791
protein coding gene Chr4:117783105-117787993 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028661
protein coding gene Chr4:118931670-118935271 (-)
A/J MGP_AJ_G0028622
protein coding gene Chr4:114346237-114349838 (-)
AKR/J MGP_AKRJ_G0028572
protein coding gene Chr4:116849682-116853282 (-)
BALB/cJ MGP_BALBcJ_G0028643
protein coding gene Chr4:114982151-114985751 (-)
C3H/HeJ MGP_C3HHeJ_G0028357
protein coding gene Chr4:118424767-118428367 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029084
protein coding gene Chr4:123509767-123513368 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026368
protein coding gene Chr4:108371975-108375598 (-)
CAST/EiJ MGP_CASTEiJ_G0027791
protein coding gene Chr4:115652769-115656383 (-)
CBA/J MGP_CBAJ_G0028324
protein coding gene Chr4:126880288-126883888 (-)
DBA/2J MGP_DBA2J_G0028472
protein coding gene Chr4:114960975-114964576 (-)
FVB/NJ MGP_FVBNJ_G0028440
protein coding gene Chr4:113476385-113479985 (-)
LP/J MGP_LPJ_G0028574
protein coding gene Chr4:119120334-119123935 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028467
protein coding gene Chr4:131797433-131801033 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029121
protein coding gene Chr4:117996484-118000085 (-)
PWK/PhJ MGP_PWKPhJ_G0027517
protein coding gene Chr4:111781848-111785503 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027340
protein coding gene Chr4:114308599-114312203 (-)
WSB/EiJ MGP_WSBEiJ_G0027870
protein coding gene Chr4:117876756-117880356 (-)



Homology
more
  • Human Ortholog
    ARTN, artemin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARTN, artemin
  • Synonyms
    ART, ENOVIN, EVN, NBN
  • Links
    NCBI Gene ID: 9048
    neXtProt AC: NX_Q5T4W7
    UniProt: Q5T4W7

  • Chr Location
    1p34.1; chr1:43933320-43937240 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene display ptosis and poor development of the sympathetic chain ganglia and associated nerves.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028539 Ensembl Gene Model | MGI Sequence Detail 3602 C57BL/6J ±  kb
    transcript ENSMUST00000097913 Ensembl | MGI Sequence Detail 1568 Not Applicable  
    polypeptide ENSMUSP00000095526 Ensembl | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 3
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:51795 Baloh RH, et al., Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron. 1998 Dec;21(6):1291-302
    • Latest
      J:290965 Edamitsu T, et al., Aryl Hydrocarbon Receptor Directly Regulates Artemin Gene Expression. Mol Cell Biol. 2019 Oct 15;39(20)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory