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Epn1 Gene Detail
Summary
  • Symbol
    Epn1
  • Name
    epsin 1
  • Synonyms
    Ibp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333763
    NCBI Gene: 13854
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:5083234-5101177 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    485 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333763
 protein coding gene Chr7:5083207-5101178 (+)
129S1/SvImJ ENSMUSG00200040596
 protein coding gene Chr7:1814304-1832281 (+)
A/J ENSMUSG00195051113
 protein coding gene Chr7:1805135-1823117 (+)
AKR/J ENSMUSG00220022503
 protein coding gene Chr7:2272130-2290112 (-)
BALB/cJ ENSMUSG00180043160
 protein coding gene Chr7:1760345-1778319 (+)
C3H/HeJ ENSMUSG00175042554
 protein coding gene Chr7:1768033-1786014 (+)
C57BL/6NJ ENSMUSG00215042125
 protein coding gene Chr7:1806064-1824019 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029151
 protein coding gene Chr7:1757421-1775155 (+)
CAST/EiJ ENSTCUG00005024502
 protein coding gene Chr7:1977801-1995756 (+)
CBA/J ENSMUSG00210043623
 protein coding gene Chr7:1766473-1784457 (+)
DBA/2J ENSMUSG00185043380
 protein coding gene Chr7:1948939-1966919 (+)
FVB/NJ ENSMUSG00205044893
 protein coding gene Chr7:1747115-1765090 (+)
JF1/MsJ ENSUMUG00000035545
 protein coding gene Chr7:2014360-2032926 (+)
LP/J ENSMUSG00230039288
 protein coding gene Chr7:4959753-4977716 (+)
NOD/ShiLtJ ENSMUSG00190041311
 protein coding gene Chr7:1838925-1856897 (+)
NZO/HlLtJ ENSMUSG00225020916
 protein coding gene Chr7:2873956-2891884 (+)
PWK/PhJ ENSLUMG00010046554
 protein coding gene Chr7:5526846-5548082 (+)
SPRET/EiJ ENSMSPG00010046570
 protein coding gene Chr7:1937376-1955572 (+)
WSB/EiJ ENSIUOG00005047706
 protein coding gene Chr7:1766745-1784679 (+)



Homology
more
  • Human Ortholog
    EPN1, epsin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPN1, epsin 1
  • Links
    NCBI Gene ID: 29924
    UniProt: Q9Y6I3

  • Chr Location
    19q13.42; chr19:55675109-55709858 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    30 phenotypes from multigenic genotypes
    7 images
    16 phenotype references
Mice homozygous for a null mutation are viable and fertile with no gross abnormalities. Mice homozygous null for both Epn1 and Epn2 display defects in angiogenic vascular remodeling, impaired somitogenesis and extensive cell death in the nervous tissue, resulting in lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    1
  • cDNA Data
    75
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035203 Ensembl Gene Model | MGI Sequence Detail 17944 C57BL/6J ±  kb
transcript ENSMUST00000208634 Ensembl | MGI Sequence Detail 2127 Not Applicable  
polypeptide ENSMUSP00000146638 Ensembl | MGI Sequence Detail 576 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    Genomic 2
    cDNA 75
    Antibodies 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141801
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:51614 Yamabhai M, et al., Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. J Biol Chem. 1998 Nov 20;273(47):31401-7
  • Latest
    J:379361 Arulsamy K, et al., Single-Cell Analysis Reveals a Critical Role for Macrophage Epsins in Regulating the Origin of Foam Cells in Atherosclerosis. Arterioscler Thromb Vasc Biol. 2025 Nov;45(11):e523-e543
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory