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Pigq Gene Detail
Summary
  • Symbol
    Pigq
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class Q
  • Synonyms
    Gpi1, Gpi1h, Gpi1p, Gpih
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333114
    NCBI Gene: 14755
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:26145398-26161855 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 13.01 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    408 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333114
 protein coding gene Chr17:26145395-26163910 (-)
129S1/SvImJ ENSMUSG00200046994
 protein coding gene Chr17:21590435-21601476 (-)
A/J ENSMUSG00195054236
 protein coding gene Chr17:22607574-22618618 (-)
AKR/J ENSMUSG00220052142
 protein coding gene Chr17:21654399-21665437 (-)
BALB/cJ ENSMUSG00180049545
 protein coding gene Chr17:21888448-21899492 (-)
C3H/HeJ ENSMUSG00175053554
 protein coding gene Chr17:21646639-21657680 (-)
C57BL/6NJ ENSMUSG00215053161
 protein coding gene Chr17:21655001-21666042 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021264
 protein coding gene Chr17:21764570-21782109 (-)
CAST/EiJ ENSTCUG00005047703
 protein coding gene Chr17:22236438-22247414 (-)
CBA/J ENSMUSG00210049311
 protein coding gene Chr17:21485475-21496516 (-)
DBA/2J ENSMUSG00185052439
 protein coding gene Chr17:23695824-23706868 (-)
FVB/NJ ENSMUSG00205024737
 protein coding gene Chr17:21951559-21962600 (-)
JF1/MsJ ENSUMUG00000054508
 protein coding gene Chr17:23151495-23162227 (-)
LP/J ENSMUSG00230054587
 protein coding gene Chr17:25094968-25106009 (-)
NOD/ShiLtJ ENSMUSG00190040828
 protein coding gene Chr17:21584542-21595586 (-)
NZO/HlLtJ ENSMUSG00225053946
 protein coding gene Chr17:27014896-27025937 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010047537
 protein coding gene Chr17:22388262-22406672 (-)
WSB/EiJ ENSIUOG00005050776
 protein coding gene Chr17:22328275-22339272 (-)



Homology
more
  • Human Ortholog
    PIGQ, phosphatidylinositol glycan anchor biosynthesis class Q
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGQ, phosphatidylinositol glycan anchor biosynthesis class Q
  • Synonyms
    c407A10.1, DEE77, EIEE77, GPI1, GPIBD19, MCAHS4
  • Links
    NCBI Gene ID: 9091
    UniProt: Q9BRB3

  • Chr Location
    16p13.3; chr16:566995-584120 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PIGQ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a transposon-induced allele exhibit lethality at E12.5 and have cardiac, vascular system, and liver abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    138
  • cDNA Data
    152
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14755 NCBI Gene Model | MGI Sequence Detail 16458 C57BL/6J ±  kb
    transcript NM_001291025 RefSeq | MGI Sequence Detail 3234 C57BL/6  
    polypeptide Q9QYT7 UniProt | EBI | MGI Sequence Detail 581 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • Protein Ontology
      PR:000012704 phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
      (term hierarchy)
    • InterPro Domains
      IPR007720 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q/GPI1
    Molecular
    Reagents
    less
    • All nucleic 154
      cDNA 154

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1345628
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:50634 Tiede A, et al., Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. Biochem J. 1998 Sep 15;334(Pt 3):609-16
    • Latest
      J:378174 Yan B, et al., Embryonic Lethal Phenotyping to Identify Candidate Genes Related with Birth Defects. Int J Mol Sci. 2024 Aug 13;25(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory