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Amd2 Gene Detail
Summary
  • Symbol
    Amd2
  • Name
    S-adenosylmethionine decarboxylase 2
  • Synonyms
    Amd3, ENSMUSG00000063953
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333111
    NCBI Gene: 100041585
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr10:35584687-35587887 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 19.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    7
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333111
 protein coding gene Chr10:35584671-35587888 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036210
 protein coding gene ChrX:153036807-153040183 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0030746
 protein coding gene Chr6:69931854-69933852 (+)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0028710
 protein coding gene Chr4:51579343-51582893 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0036105
 protein coding gene ChrX:154139497-154141207 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0028745
 protein coding gene Chr4:49425108-49428091 (-)
PWK/PhJ MGP_PWKPhJ_G0029652
 protein coding gene Chr6:66149771-66153273 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    AMD1, adenosylmethionine decarboxylase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMD1, adenosylmethionine decarboxylase 1
  • Synonyms
    ADOMETDC, AMD, SAMDC
  • Links
    NCBI Gene ID: 262
    neXtProt AC: NX_P17707
    UniProt: P17707

  • Chr Location
    6q21; chr6:110814617-110898879 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AMD1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Amd2
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    4 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    947
  • Tissues
    112
  • cDNA Data
    1
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100041585 NCBI Gene Model | MGI Sequence Detail 3201 C57BL/6J ±  kb
transcript NM_007444 RefSeq | MGI Sequence Detail 3201 Not Specified  
polypeptide D3Z6H8 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 2
    cDNA 3
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGI:3642545
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:277331 Sah RK, et al., Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing. PLoS One. 2019;14(7):e0213702
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory