Bcl7b MGI Mouse Gene Detail - MGI:1332238

Symbol

Bcl7b
Name

B cell CLL/lymphoma 7B

Feature Type

protein coding gene
IDs

MGI:1332238
NCBI Gene: 12054
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr5:135197226-135210706 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 75.04 cM
Mapping Data

5 experiments

SNPs within 2kb

395 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1332238	protein coding gene	Chr5:135197137-135210709 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030176	protein coding gene	Chr5:139669789-139683308 (+)
A/J	MGP_AJ_G0030144	protein coding gene	Chr5:133696642-133710225 (+)
AKR/J	MGP_AKRJ_G0030077	protein coding gene	Chr5:138041795-138055270 (+)
BALB/cJ	MGP_BALBcJ_G0030154	protein coding gene	Chr5:135053649-135067213 (+)
C3H/HeJ	MGP_C3HHeJ_G0029870	protein coding gene	Chr5:138604027-138617560 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030607	protein coding gene	Chr5:144900233-144913782 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027830	protein coding gene	Chr5:127991954-128007067 (+)
CAST/EiJ	MGP_CASTEiJ_G0029279	protein coding gene	Chr5:138019321-138033991 (+)
CBA/J	MGP_CBAJ_G0029840	protein coding gene	Chr5:150572599-150586125 (+)
DBA/2J	MGP_DBA2J_G0029991	protein coding gene	Chr5:133597415-133610995 (+)
FVB/NJ	MGP_FVBNJ_G0029946	protein coding gene	Chr5:132732028-132745678 (+)
LP/J	MGP_LPJ_G0030079	protein coding gene	Chr5:140116120-140130386 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029978	protein coding gene	Chr5:153582623-153596164 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030647	protein coding gene	Chr5:137786793-137802603 (+)
PWK/PhJ	MGP_PWKPhJ_G0028994	protein coding gene	Chr5:132639623-132653224 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028829	protein coding gene	Chr5:135351875-135365339 (+)
WSB/EiJ	MGP_WSBEiJ_G0029353	protein coding gene	Chr5:138539186-138552818 (+)

Human Ortholog

BCL7B, BAF chromatin remodeling complex subunit BCL7B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCL7B, BAF chromatin remodeling complex subunit BCL7B
Synonyms

SMARCJ2
Links

HGNC:1005

NCBI Gene ID: 9275

UniProt: Q9BQE9
Chr Location

7q11.23; chr7:73536356-73557690 (-) GRCh38

MGI Vertebrate Homology

Bcl7b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BCL7B
Gene Tree

Bcl7b

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References

2 with disease annotations

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

106
Endonuclease-mediated

3
Gene trapped

96
Targeted

7
Genomic Mutations

2 involving Bcl7b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

75 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation are viable with no gross developmental, motor coordination, or memory formation abnormalities.

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All GO Annotations

20
GO References

16

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

781
Tissues

35
cDNA Data

11
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bcl7b

ZFIN bcl7ba, bcl7bb

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All Sequences

49
RefSeq

2
UniProt

3
CCDS

CCDS51660.1

Ensembl

ENSMUSG00000029681 (Evidence)
NCBI Gene

12054

			Length	Strain/Species	Flank
genomic	12054	NCBI Gene Model \| MGI Sequence Detail	13481	C57BL/6J	± kb
transcript	NM_009745	RefSeq \| MGI Sequence Detail	1678	C57BL/6
polypeptide	Q921K9	UniProt \| EBI \| MGI Sequence Detail	202	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004702 B-cell CLL/lymphoma 7 protein family member B

(term hierarchy)
InterPro Domains

IPR006804 BCL7
GlyGen

Q921K9 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 21

Genomic 5

cDNA 11

Primer pair 4

Other 1

Microarray probesets 3

Summaries

All 69

Developmental Gene Expression 5

Diseases 2

Gene Ontology 16

Phenotypes 27
Earliest

J:35263 Wang W, et al., Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 1996 Sep 1;10(17):2117-30
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bcl7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49142	Chr5:135197205-135197227 (+)	-10 bp
Tssr49143	Chr5:135197236-135197296 (+)	40 bp
Tssr49144	Chr5:135197297-135197356 (+)	101 bp
Tssr49145	Chr5:135197379-135197388 (+)	158 bp
Tssr49146	Chr5:135197776-135197809 (+)	567 bp
Tssr49147	Chr5:135197871-135197877 (+)	648 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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