Sprr2f MGI Mouse Gene Detail - MGI:1330349 - small proline-rich protein 2F

Symbol

Sprr2f
Name

small proline-rich protein 2F

Feature Type

protein coding gene
IDs

MGI:1330349
NCBI Gene: 20760
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr3:92272494-92273749 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.14 cM
Mapping Data

4 experiments

SNPs within 2kb

36 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330349	protein coding gene	Chr3:92272494-92273754 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027491	protein coding gene	Chr3:92808164-92809419 (+)
A/J	MGP_AJ_G0027458	protein coding gene	Chr3:89887678-89888933 (+)
AKR/J	MGP_AKRJ_G0027423	protein coding gene	Chr3:91989749-91991004 (+)
BALB/cJ	MGP_BALBcJ_G0027467	protein coding gene	Chr3:89698781-89700038 (+)
C3H/HeJ	MGP_C3HHeJ_G0027206	protein coding gene	Chr3:92214399-92215654 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027910	protein coding gene	Chr3:96343881-96345136 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025261	protein coding gene	Chr3:86529765-86531102 (+)
CAST/EiJ	MGP_CASTEiJ_G0026654	protein coding gene	Chr3:91624181-91625462 (+)
CBA/J	MGP_CBAJ_G0027181	protein coding gene	Chr3:99639104-99640359 (+)
DBA/2J	MGP_DBA2J_G0027318	protein coding gene	Chr3:89207995-89209250 (+)
FVB/NJ	MGP_FVBNJ_G0027286	protein coding gene	Chr3:87374116-87375371 (+)
LP/J	MGP_LPJ_G0027427	protein coding gene	Chr3:94026804-94028059 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027310	protein coding gene	Chr3:105887500-105888755 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027969	protein coding gene	Chr3:91719619-91720874 (+)
PWK/PhJ	MGP_PWKPhJ_G0026387	protein coding gene	Chr3:89096092-89097346 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026206	protein coding gene	Chr3:90045933-90047377 (+)
WSB/EiJ	MGP_WSBEiJ_G0026736	protein coding gene	Chr3:92113482-92114737 (+)

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Gene Tree

Sprr2f

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Sprr2f
Find Mice (IMSR)

14 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous knockout affects sensitivity to oxidative stress, resulting in increased kidney damage and fibrosis after ischemia-reperfusion injury and unilateral ureteral obstruction, respectively.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

5
Literature Summary

6

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS57226.1

Ensembl

ENSMUSG00000050635 (Evidence)
NCBI Gene

20760

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050635	Ensembl Gene Model \| MGI Sequence Detail	1256	C57BL/6J	± kb
transcript	ENSMUST00000050397	Ensembl \| MGI Sequence Detail	609	Not Applicable
polypeptide	ENSMUSP00000050902	Ensembl \| MGI Sequence Detail	76	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR029142 Small proline-rich protein 2

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All nucleic 13

Genomic 8

cDNA 5

Microarray probesets 3

Summaries

All 34

Developmental Gene Expression 6

Diseases 1

Gene Ontology 4

Phenotypes 9
Earliest

J:113697 Gibbs S, et al., Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. Genomics. 1993 Jun;16(3):630-7
Latest

J:299874 Huynh KM, et al., Sprr2f protects against renal injury by decreasing the level of reactive oxygen species in female mice. Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F876-F884

TSS for Sprr2f:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30285	Chr3:92272455-92272463 (+)	-35 bp
Tssr30286	Chr3:92272485-92272500 (+)	-1 bp
Tssr30287	Chr3:92273188-92273197 (+)	699 bp
Tssr30288	Chr3:92273343-92273353 (+)	854 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23