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Sprr2i Gene Detail
Summary
  • Symbol
    Sprr2i
  • Name
    small proline-rich protein 2I
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330309
    NCBI Gene: 20763
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:92315298-92316577 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330309
 protein coding gene Chr3:92315298-92316578 (+)
129S1/SvImJ ENSMUSG00200036040
 protein coding gene Chr3:89102856-89104136 (+)
A/J ENSMUSG00195052162
 protein coding gene Chr3:89112498-89113778 (+)
AKR/J ENSMUSG00220047481
 protein coding gene Chr3:88333303-88334583 (+)
BALB/cJ ENSMUSG00180043124
 protein coding gene Chr3:89278075-89279355 (+)
C3H/HeJ ENSMUSG00175046865
 protein coding gene Chr3:89050340-89051620 (+)
C57BL/6NJ ENSMUSG00215046987
 protein coding gene Chr3:89661689-89662969 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025263
 protein coding gene Chr3:86576310-86577616 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210040069
 protein coding gene Chr3:89165545-89166825 (+)
DBA/2J ENSMUSG00185050144
 protein coding gene Chr3:89368717-89369997 (+)
FVB/NJ ENSMUSG00205039566
 protein coding gene Chr3:88135993-88137273 (+)
JF1/MsJ ENSUMUG00000013187
 protein coding gene Chr3:88907583-88908862 (+)
LP/J ENSMUSG00230027309
 protein coding gene Chr3:91400347-91401627 (+)
NOD/ShiLtJ ENSMUSG00190046447
 protein coding gene Chr3:89496189-89497469 (+)
NZO/HlLtJ ENSMUSG00225009196
 protein coding gene Chr3:94249438-94250718 (+)
PWK/PhJ ENSLUMG00010048006
 protein coding gene Chr3:88968413-88969693 (+)
SPRET/EiJ ENSMSPG00010049815
 protein coding gene Chr3:89428021-89429016 (+)
WSB/EiJ ENSIUOG00005046510
 protein coding gene Chr3:89647107-89648387 (+)



Homology
more
  • Human Ortholog
    SPRR2A, small proline rich protein 2A
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPRR2A, small proline rich protein 2A
  • Links
    NCBI Gene ID: 6700
    UniProt: P35326

  • Chr Location
    1q21.3; chr1:153056120-153057512 (-)  GRCh38
  • Human Ortholog
    SPRR2B, small proline rich protein 2B
  • Links
    NCBI Gene ID: 6701
    UniProt: P35325

  • Chr Location
    1q21.3; chr1:153070226-153087799 (-)  GRCh38
  • Human Ortholog
    SPRR2D, small proline rich protein 2D
  • Links
    NCBI Gene ID: 6703
    UniProt: P22532

  • Chr Location
    1q21.3; chr1:153039732-153041931 (-)  GRCh38
  • Human Ortholog
    SPRR2E, small proline rich protein 2E
  • Links
    NCBI Gene ID: 6704
    UniProt: P22531

  • Chr Location
    1q21.3; chr1:153093135-153106184 (-)  GRCh38
  • Human Ortholog
    SPRR2F, small proline rich protein 2F
  • Links
    NCBI Gene ID: 6705
    UniProt: Q96RM1

  • Chr Location
    1q21.3; chr1:153112121-153119468 (-)  GRCh38
  • Human Ortholog
    SPRR2G, small proline rich protein 2G
  • Links
    NCBI Gene ID: 6706
    UniProt: Q9BYE4

  • Chr Location
    1q21.3; chr1:153149582-153203278 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Sprr2i
  • Find Mice (IMSR)
    6 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    3
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20763 NCBI Gene Model | MGI Sequence Detail 1280 C57BL/6J ±  kb
transcript NM_011475 RefSeq | MGI Sequence Detail 616 ZRU/MplStud  
polypeptide O70560 UniProt | EBI | MGI Sequence Detail 76 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 6
    cDNA 3

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:113697 Gibbs S, et al., Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. Genomics. 1993 Jun;16(3):630-7
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory