Trpm1 MGI Mouse Gene Detail - MGI:1330305 - transient receptor potential cation channel, subfamily M, member 1

Symbol

Trpm1
Name

transient receptor potential cation channel, subfamily M, member 1
Synonyms

4732499L03Rik, LTRPC1, melastatin, Mlsn1

Feature Type

protein coding gene
IDs

MGI:1330305
NCBI Gene: 17364
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:63803583-63919523 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, Syntenic
Mapping Data

3 experiments

SNPs within 2kb

3564 from dbSNP Build 142
Strain Annotations

27
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1330305	protein coding gene	Chr7:63803583-63923630 (+)
129S1/SvImJ	ENSMUSG00200008030	protein coding gene	Chr7:50543655-50614592 (+)
129S1/SvImJ	ENSMUSGG00200054561	protein coding gene	Chr7:50635724-50657295 (+)
A/J	ENSMUSGG00195054918	protein coding gene	Chr7:55053355-55075431 (+)
A/J	ENSMUSG00195012437	protein coding gene	Chr7:54961167-55032195 (+)
AKR/J	ENSMUSGG00220054704	protein coding gene	Chr7:48561149-48582725 (+)
AKR/J	ENSMUSG00220010795	protein coding gene	Chr7:48469095-48540023 (+)
BALB/cJ	ENSMUSG00180004573	protein coding gene	Chr7:51686947-51757984 (+)
BALB/cJ	ENSMUSGG00180055150	protein coding gene	Chr7:51779154-51801227 (+)
C3H/HeJ	ENSMUSG00175010280	protein coding gene	Chr7:52414143-52485076 (+)
C3H/HeJ	ENSMUSGG00175054909	protein coding gene	Chr7:52506207-52527778 (+)
C57BL/6NJ	ENSMUSG00215016340	protein coding gene	Chr7:51597646-51668637 (+)
C57BL/6NJ	ENSMUSGG00215055553	protein coding gene	Chr7:51689797-51711874 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029825	protein coding gene	Chr7:66972098-67087371 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210054862	protein coding gene	Chr7:52402310-52423876 (+)
CBA/J	ENSMUSG00210019612	protein coding gene	Chr7:52310269-52381179 (+)
DBA/2J	ENSMUSGG00185057478	protein coding gene	Chr7:56755420-56777297 (+)
DBA/2J	ENSMUSG00185005925	protein coding gene	Chr7:56663690-56734356 (+)
FVB/NJ	ENSMUSGG00205054506	protein coding gene	Chr7:52347520-52369597 (+)
FVB/NJ	ENSMUSG00205003850	protein coding gene	Chr7:52255351-52326357 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230017172	protein coding gene	Chr7:62671903-62742906 (+)
LP/J	ENSMUSGG00230055657	protein coding gene	Chr7:62764062-62786138 (+)
NOD/ShiLtJ	ENSMUSG00190006911	protein coding gene	Chr7:52419185-52490138 (+)
NOD/ShiLtJ	ENSMUSGG00190054859	protein coding gene	Chr7:52511269-52532840 (+)
NZO/HlLtJ	ENSMUSG00225016222	protein coding gene	Chr7:60957591-61028468 (+)
NZO/HlLtJ	ENSMUSGG00225055455	protein coding gene	Chr7:61049625-61071701 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010002944	protein coding gene	Chr7:51324453-51447468 (+)
WSB/EiJ	no annotation

Human Ortholog

TRPM1, transient receptor potential cation channel subfamily M member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRPM1, transient receptor potential cation channel subfamily M member 1
Synonyms

CSNB1C, LTRPC1, MLSN1
Links

HGNC:7146

NCBI Gene ID: 4308

UniProt: Q7Z4N2
Chr Location

15q13.3; chr15:31001065-31161160 (-) GRCh38

MGI Vertebrate Homology

Trpm1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TRPM1
Gene Tree

Trpm1

Diseases

1 with Trpm1 mouse models; 2 with human TRPM1 associations

Human Disease

Mouse Models

congenital stationary night blindness 1C

IDs

View 2 models

congenital stationary night blindness

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

4 with disease annotations

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Phenotype Summary

19 phenotypes from 6 alleles in 8 genetic backgrounds
61 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Spontaneous

2
Targeted

8
Genomic Mutations

7 involving Trpm1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

101 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses.

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All GO Annotations

43
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

63
cDNA Data

41
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trpm1

ZFIN trpm1a, trpm1b

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All Sequences

520
RefSeq

8
UniProt

10
CCDS

CCDS21332.2, CCDS39975.2

Ensembl

ENSMUSG00000030523 (Evidence)
NCBI Gene

17364

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030523	Ensembl Gene Model \| MGI Sequence Detail	115941	C57BL/6J	± kb
transcript	ENSMUST00000206277	Ensembl \| MGI Sequence Detail	5076	Not Applicable
polypeptide	ENSMUSP00000146226	Ensembl \| MGI Sequence Detail	1628	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000016697 transient receptor potential cation channel subfamily M member 1

(term hierarchy)
PDB

6RMV
InterPro Domains

IPR005821 Ion transport domain

IPR050927 Transient receptor potential cation channel subfamily M

IPR057366 TRPM-like domain

IPR041491 TRPM, SLOG domain

IPR032415 TRPM, tetramerisation domain

IPR037162 TRPM, tetramerisation domain superfamily
GlyGen

Q2TV84 2 sites

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All nucleic 51

Genomic 4

cDNA 42

Primer pair 5

Microarray probesets 5

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MGI:2142011, MGI:3036274, MGI:4867500

Summaries

All 122

Developmental Gene Expression 16

Diseases 4

Gene Ontology 16

Phenotypes 61
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:390014 Horie S, et al., A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness. J Gen Physiol. 2025 Nov 3;157(6)

TSS for Trpm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66997	Chr7:63803589-63803599 (+)	11 bp
Tssr66998	Chr7:63803610-63803613 (+)	29 bp
Tssr66999	Chr7:63803664-63803671 (+)	85 bp
Tssr67000	Chr7:63803690-63803697 (+)	111 bp
Tssr67001	Chr7:63808701-63808709 (+)	5,122 bp
Tssr67002	Chr7:63835154-63835170 (+)	31,579 bp
Tssr67003	Chr7:63835243-63835254 (+)	31,666 bp
Tssr67004	Chr7:63835285-63835308 (+)	31,714 bp
Tssr67006	Chr7:63876327-63876332 (+)	72,747 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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