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Gk2 Gene Detail
Summary
  • Symbol
    Gk2
  • Name
    glycerol kinase 2
  • Synonyms
    Gk-rs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329027
    NCBI Gene: 14626
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:97603001-97604880 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 47.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329027
 protein coding gene Chr5:97602989-97604882 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029770
 protein coding gene Chr5:98749520-98751399 (-)
A/J MGP_AJ_G0029736
 protein coding gene Chr5:95113791-95115670 (-)
AKR/J MGP_AKRJ_G0029682
 protein coding gene Chr5:98281716-98283595 (-)
BALB/cJ MGP_BALBcJ_G0029746
 protein coding gene Chr5:96118082-96119961 (-)
C3H/HeJ MGP_C3HHeJ_G0029469
 protein coding gene Chr5:98617202-98619081 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030201
 protein coding gene Chr5:102922987-102924866 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027436
 protein coding gene Chr5:90461449-90463328 (-)
CAST/EiJ MGP_CASTEiJ_G0028880
 protein coding gene Chr5:97226625-97228504 (-)
CBA/J MGP_CBAJ_G0029439
 protein coding gene Chr5:106471292-106473171 (-)
DBA/2J MGP_DBA2J_G0029583
 protein coding gene Chr5:95322583-95324462 (-)
FVB/NJ MGP_FVBNJ_G0029542
 protein coding gene Chr5:94147078-94148957 (-)
LP/J MGP_LPJ_G0029671
 protein coding gene Chr5:99389167-99391046 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029571
 protein coding gene Chr5:111544817-111546696 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030234
 protein coding gene Chr5:97729852-97731731 (-)
PWK/PhJ MGP_PWKPhJ_G0028598
 protein coding gene Chr5:93712705-93714584 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028433
 protein coding gene Chr5:95388267-95390146 (-)
WSB/EiJ MGP_WSBEiJ_G0028958
 protein coding gene Chr5:98034885-98036764 (-)



Homology
more
  • Human Ortholog
    GK2, glycerol kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GK2, glycerol kinase 2
  • Synonyms
    GKP2, GKTA
  • Links
    NCBI Gene ID: 2712
    neXtProt AC: NX_Q14410
    UniProt: Q14410

  • Chr Location
    4q21.21; chr4:79406361-79408228 (-)  GRCh38
  • MGI Vertebrate Homology
    Gk2 stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: GK2
  • Protein SuperFamily
    GlpK
  • Gene Tree
    Gk2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 5 alleles in 5 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The gene product is involved in mitochondrial dynamics in sperm cells. Homozygous KO causes sperm motility defects which leads to male infertility, but does not result in alopecia or hair growth abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    31
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050553 Ensembl Gene Model | MGI Sequence Detail 1880 C57BL/6J ±  kb
    transcript ENSMUST00000059657 Ensembl | MGI Sequence Detail 1880 Not Applicable  
    polypeptide ENSMUSP00000052226 Ensembl | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 1
      cDNA 31
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:302631 Shimada K, et al., ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2018355118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory