Slfn3 MGI Mouse Gene Detail - MGI:1329005

Symbol

Slfn3
Name

schlafen 3

Feature Type

protein coding gene
IDs

MGI:1329005
NCBI Gene: 20557
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:83082156-83105980 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.30 cM, cytoband B5
Mapping Data

2 experiments

SNPs within 2kb

59 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1329005	protein coding gene	Chr11:83082156-83105980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018842	protein coding gene	Chr11:84505169-84533069 (+)
A/J	MGP_AJ_G0018809	protein coding gene	Chr11:81300650-81324242 (+)
AKR/J	MGP_AKRJ_G0018779	protein coding gene	Chr11:83706352-83730918 (+)
BALB/cJ	MGP_BALBcJ_G0018782	protein coding gene	Chr11:81706246-81727334 (+)
C3H/HeJ	MGP_C3HHeJ_G0018596	protein coding gene	Chr11:83756183-83785470 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019234	protein coding gene	Chr11:87096793-87127099 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016868	protein coding gene	Chr11:78088059-78090848 (+)
CAST/EiJ	MGP_CASTEiJ_G0018151	protein coding gene	Chr11:84380908-84383550 (+)
CBA/J	MGP_CBAJ_G0018567	protein coding gene	Chr11:90877245-90905813 (+)
DBA/2J	MGP_DBA2J_G0018675	protein coding gene	Chr11:80864447-80890651 (+)
FVB/NJ	MGP_FVBNJ_G0018664	protein coding gene	Chr11:80381911-80403773 (+)
LP/J	MGP_LPJ_G0018745	protein coding gene	Chr11:85041905-85119498 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018691	protein coding gene	Chr11:91040308-91066375 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019274	protein coding gene	Chr11:83984512-84009732 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0017712	protein coding gene	Chr11:83532827-83558514 (+)
WSB/EiJ	MGP_WSBEiJ_G0018202	protein coding gene	Chr11:83853803-83878886 (+)

Human Ortholog

SLFN12, schlafen family member 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLFN12, schlafen family member 12
Synonyms

SLFN3
Links

HGNC:25500

NCBI Gene ID: 55106

neXtProt AC: NX_Q8IYM2

UniProt: Q8IYM2
Chr Location

17q12; chr17:35410922-35433283 (-) GRCh38

Human Ortholog

SLFN12L, schlafen family member 12 like
Links

HGNC:33920

NCBI Gene ID: 100506736

neXtProt AC: NX_Q6IEE8

UniProt: Q6IEE8
Chr Location

chr17:35464249-35537678 (-) GRCh38

MGI Vertebrate Homology

Slfn3 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLFN12, SLFN12L
Gene Tree

Slfn3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

2 involving Slfn3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available

Mice homozygous for a null allele exhibit normal immune cell populations and MOG-induced experimental autoimmune encephalitis development.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

94
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS25159.1

Ensembl

ENSMUSG00000018986 (Evidence)
NCBI Gene

20557

			Length	Strain/Species	Flank
genomic	20557	NCBI Gene Model \| MGI Sequence Detail	23825	C57BL/6J	± kb
transcript	NM_011409	RefSeq \| MGI Sequence Detail	1834	Not Specified
polypeptide	NP_035539	RefSeq \| MGI Sequence Detail	517	Not Specified

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UniProt

3 Sequences
InterPro Domains

IPR031450 Poxin-Schlafen/Schlafen-like, N-terminal domain

IPR007421 Schlafen, AlbA_2 domain

IPR038461 Schlafen, AlbA_2 domain superfamily

IPR029684 Schlafen family

IPR048729 Schlafen, GTPase-like domain

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All nucleic 10

Genomic 1

cDNA 8

Primer pair 1

Microarray probesets 5

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:344682 Vomhof-DeKrey EE, et al., Vil-Cre specific Slfn3KO mice exhibit sex-specific differences in lung, stomach, cecum, kidney, and proximal colon differentiation markers and Slfn family members expression levels. Biochem Biophys Rep. 2023 Dec;36:101552

TSS for Slfn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103669	Chr11:83082122-83082142 (+)	-24 bp
Tssr103670	Chr11:83082152-83082165 (+)	3 bp
Tssr103671	Chr11:83082167-83082183 (+)	19 bp
Tssr103672	Chr11:83086356-83086369 (+)	4,207 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23